Auditory Pathways Flashcards

1
Q

How are frequency and amplitude measured?

A

Frequency - Hertz = pitch

Amplitude - decibels = loudness

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2
Q

What is the logic for why the pressure calculation for decibels is multiplied by 20 rather than 10?

A

decibel scale multiplication by 10 is based on the intensity of sound. Intensity = Pressure^2. Since you take the log of pressure^2, 2log Pressure is the same as this. 102 = 20. This is all based on the intensity or pressure of a standard sound which is the threshold of human hearing

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3
Q

What is the range of human hearing, and where is it most sensitive?

A

20-20,000 Hz, most sensitive 1,000-3,000 Hz. Outside of this range, you need more than 0 dB of intensity in order to hear. Your hearing degenerates (curve moves above 0 dB in optimal range) as you age.

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4
Q

What device is used to detect an individual’s threshold of hearing?

A

Audiometer

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5
Q

How loud does something have to be before you can feel it?

A

140 dB

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6
Q

What is the approximate natural frequency of the external ear?

A

3000 Hz

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7
Q

What is the function of the middle ear ossicles? What frequencies is it good at?

A

Impedance match the air (tympanic membrane) with the inner ear (oval window). Since the foot of the stapes is so much small than the energy being taken on the tympanic membrane, 22 times as much pressure is put on the oval window than the tympanic membrane.

Its resonant frequency is ~ 1400 Hz, and is best in the range of 600-6000 Hz.

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8
Q

What muscles are involved in the attuenation reflex?

A

Tensor tympani - insertion to malleus, via V3

Stapedius - insertion to stapes, via 7

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9
Q

What two compartments border the Organ of Corti? What fills them?

A

Scala media - between Scala tympani + scala vestibuli. Filled with endolymph - high K+ / low Na+

Scala tympani - below basilar membrane - filled with perilymph - high Na+, low K+.

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10
Q

What compartment is directly adjacent to the oval and round windows?

A

Oval - scala vestibuli, separated from scala media via Reissner’s membrane.
Round - Scala tympani.

Scala tympani + scala vestibuli are continous at the helicotrema, at the apex of the modiolus (the bone).

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11
Q

Where are high and low frequencies carried by the basilar membrane, and how does this excite hairs?

A

High: Near the base
Low: near the apex

excites hairs by moving basilar membrane and depolarizing towards kinocilium of the inner hair cells via pulling on the tectorial membrane.

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12
Q

What is the function of the inner hair cells vs outer hair cells and where do they synapse?

A

Inner hair cells: one row, involved in the main processing of sound

Outer hair cells: four rows, involved in the amplification of sound. They are separated by an arch of pilar cells.

They synapse on the peripheral processes of the cells of the spiral ganglion, releasing glutamate neurotransmitters. The central processes of these neurons form the cochlear nerve.

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13
Q

Where does CN8 enter the brain?

A

Cerebellopontine angle, which is between the medulla and the pons. Cochlear and vestibular nerves are so closely associated we call them one nerve.

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14
Q

Where are the cochlear nuclei located (cochlear nuclear complex)?

A

On the lateral surface of the inferior cerebellar peduncle, near cerebellopontine angle. This is between medulla and pons transition.

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15
Q

What happens to the cochlear nerve fibers which synapse in the cochlear nuclear complex?

A

Dorsal: axons cross midline and ascend the brain in the dorsal acoustic stria
Ventral: Axons cross midline as intermediate acoustic stria to ascending auditory pathways. Also gives axons to ventral acoustic stria to ascending auditory pathways, which gives collaterals.

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16
Q

Where do collaterals from the ventral acoustic stria synapse?

A
  1. Nucleus of trapezoid body - function unclear
  2. Superior olivary nuclear complex

-> Bilateral contributions

17
Q

What is the function of the superior olivary nuclear complex and what happens from here?

A

Receives input from both sides for comparing timing and intensity of auditory signals for sound localization. Gives off 3rd order auditory fibers, some which cross midline, and enter ascending auditory pathways.

18
Q

What are the ascending auditory pathways, comprised of dorsal, intermediate, ventral acoustic stria + 3rd order from superior olivary nucleus forming? Where does this go?

A

Lateral leminscus - found in lateral part of tegmenum of pons, ascends to terminate in inferior colliculus at caudal midbrain levels. Will also consist of uncrossed fibers from ipsilateral superior olivary nuclear complex.

19
Q

Where is the inferior colliculus and how does it communicate with the other side?

A

In the caudal midbrain, receives fibers from lateral lemniscus and nucleus of lateral lemniscus to communicate to the other side via commissure of the inferior colliculus.

20
Q

How does the inferior colliculus communicate with the diencephalon?

A

Sends auditory fibers to the medial geniculate nucleus via a tract called “brachium of inferior colliculus” which literally means arm.

21
Q

What does the medial geniculate nucleus do with the auditory fibers of the brachium of the inferior colliculus once they synapse there?

A

Sends fibers to traverse temporal gyri in temporal lobe via “auditory radiation”.

22
Q

What are the functions of the transverse temporal gyri?

A

Anterior: Primary auditory area - Brodmann 41
Posterior: Auditory association area - Brodmann 42 -like SII cortex for touch. The memory of sound

23
Q

What is ankylosis vs otosclerosis of middle ear ossicles, and what kind of deafness do they lead to?

A

Ankylosis - Fusion of ossicles
Otosclerosis - formation of new bone, causing immobility of ossicles.

Both are conductive deafness (vs sensorineural or central)

24
Q

What is a Rinne test?

A

Place the butt of a tuning fork on the mastoid process. Have the patient listen, then put it next to their ear. A normal result is they can hear better when the tuning fork is not touched against them.

Conductive hearing impairment = sounds better when touching bone than when fork is free in air. (Sound is not amplified / transmitted properly by bones).

25
Q

What is a Weber test?

A

Ping the tuning fork and place it in the center of the patient’s forehead. A normal result is the fork sounds equally loud in both ears.

Sensorineural hearing loss = patient will hear it “localize it” in better ear, based on superior olivary nuclear complex

Conductive hearing loss = patient may localize it in the worse ear. This is a strange result.

26
Q

What is an auditory evoked potential (AEP)?

A

An electrophysiological tool to find where hearing abnormalities are occurring when clinical signs / symptoms are normal.

27
Q

What are the 5 peaks generated on the AEP?

A
  1. Generated by CN8
  2. Generated at cochlear nucleus
  3. Generated at superior olive / trapezoid body
    4/5. Generated in upper pons as impulses travel thru lateral lemniscus / inferior colliculus
28
Q

What are some non-operative uses of AEP?

A

Examine hearing in newborns, or determine damage in brainstem pathways / cochlear nerve, such as acoustic neuromas or coma

29
Q

What is the surgical use of AEP?

A

Can be used as a guide for surgeon to monitor transient changes of hearing, and guide surgical procedures. It is a good predictor of gross post-op hearing.

30
Q

What is the somatotopic organization of frequencies in the transverse temporal gyri?

A

higher frequencies are more medial