AUBF - Chapter 7.3 Flashcards
CSF is formed by ultrafiltration of plasma through the:
A. Choroid plexus
B. Sagittal sinus
C. Anterior cerebral lymphatics
D. Arachnoid membrane
A. Choroid plexus
Which statement regarding CSF is true?
A. Normal values for mononuclear cells are higher for infants than for adults
B. Absolute neutrophilia is not significant if the total WBC count is less than 25/µL
C. The first aliquot of CSF should be sent to the microbiology laboratory
D. Neutrophils compose the majority of WBCs in normal CSF
A. Normal values for mononuclear cells are higher for infants than for adults
When collecting CSF, a difference between opening and closing fluid pressure greater than 100 mm H2O indicates:
A. Low CSF volume
B. Subarachnoid hemorrhage
C. Meningitis
D. Hydrocephalus
A. Low CSF volume
Which of the following findings is consistent with a subarachnoid hemorrhage rather than a traumatic tap?
A. Clearing of the fluid as it is aspirated
B. A clear supernatant after centrifugation
C. Xanthochromia
D. Presence of a protein in the sample
C. Xanthochromia
The term used to denote a high WBC count in the CSF is:
A. Empyema
B. Neutrophilia
C. Pleocytosis
D. Hyperglycorrhachia
C. Pleocytosis
Give an adult CSF values consistent with bacterial meningitis.
WBC = 2000/uL
Lympho = 5%
Mono = 15%
Eo = 0%
Neutro = 80% (increased)
Neuroectodermal cells = 0%
Given the following data, determine the corrected CSF WBC count.
CSF RBCs = 6000/uL
CSF WBCs = 150/uL
Blood RBCs = 4.0 x 10^6/uL
Blood WBCs = 5.0 x 10^3/uL
A. 8/µL
B. 142/µL
C. 120/µL
D. 145/µL
B. 142/µL
Corrected WBC count = WBCs in CSF – [(Blood WBCs × CSF RBCs) ÷ Blood RBCs]
Corrected WBC count = 150/µL – [(5,000/µL WBCs × 6,000/µL RBCs) ÷ 4,000,000/µL RBCs]
Corrected WBC count = 150/µL – 7.5/µL
Corrected WBC count = 142/µL
SITUATION: What is the most likely cause of the following CSF results?
CSF glucose = 20 mg/dL
CSF protein = 200 mg/dL
CSF lactate = 50 mg/dL (ref range: 5- 25 mg/dL)
A. Viral meningitis
B. Viral encephalitis
C. Cryptococcal meningitis
D. Acute bacterial meningitis
D. Acute bacterial meningitis
Which of the following conditions is most often associated with normal CSF glucose and protein?
A. Multiple sclerosis
B. Malignancy
C. Subarachnoid hemorrhage
D. Viral meningitis
D. Viral meningitis
The diagnosis of MS is suggested by which finding?
A. The presence of elevated protein and low glucose
B. A decreased IgG index
C. The presence of oligoclonal bands by electrophoresis
D. An increased level of CSF β-microglobulin
C. The presence of oligoclonal bands by electrophoresis
Which of the following results is consistent with fungal meningitis?
A. Normal CSF glucose
B. Pleocytosis of mixed cellularity
C. Normal CSF protein
D. High CSF lactate
B. Pleocytosis of mixed cellularity
In what suspected condition should a wet prep using a warm slide be examined?
A. Cryptococcal meningitis
B. Amoebic meningoencephalitis
C. Mycobacterium tuberculosis infection
D. Neurosyphilis
B. Amoebic meningoencephalitis
Which of the following CSF test results is most commonly increased in patients with MS?
A. Glutamine
B. Lactate
C. IgG index
D. Ammonia
C. IgG index
Which of the following is an inappropriate procedure for performing routine CSF analysis?
A. A differential is done only if the total WBC count is greater than 10/µL
B. A differential should be done on a stained CSF concentrate
C. A minimum of 30 WBCs should be differentiated
D. A Wright-stained slide should be examined, rather than a chamber differential
A. A differential is done only if the total WBC count is greater than 10/µL
Which cell is present in CSF in greater numbers in newborns than in older children or adults?
A. Eosinophils
B. Lymphocytes
C. Monocytes
D. Neutrophils
C. Monocytes
Neutrophilic pleocytosis is usually associated with all of the following except:
A. Cerebral infarction
B. Malignancy
C. Myelography
D. Neurosyphilis
D. Neurosyphilis