atypical antipsychotics

Question 1

H1 block

Answer 1

sedation, weight gain

atypical antipsychotic

Question 2

M1 block

Answer 2

dry mouth, constipation, protect against drug induced parkinsonism

atypical antipsychotic

Question 3

alpha-1 block

Answer 3

hypotension

atypical antipsychotic

Question 4

D2 block

Answer 4

prolactin elevation

atypical antipsychotic

Question 5

clozapine (Clozaril)

Answer 5

+ no EPS, treat neg and pos symptoms
- weight gain, hypotension, seizures

atypical antipsychotic

Question 6

risperadone (Risperdol)

Answer 6

+ convenient dosing, less weight gain
- more D2 antagonism, higher EPS risk, prolactin elevation

atypical antipsychotic

Question 7

olanzapine (Zyprexa)

Answer 7

+ lower EPS risk than risperadone, treats mania
- weight gain, metabolic syndrome

atypical antipsychotic

Question 8

quietapine (Seroquel)

Answer 8

+ very low EPS (weak D2 bind), moderate weight gain, high dosing range
- sedating

atypical antipsychotic

Question 9

ziprasidone (Geodon)

Answer 9

+ low EPS, lowest risk of weight gain and metabolic syndrome
- lengthen QTc interval, 2x/day w food

atypical antipsychotic

Question 10

ariprazole (Abilify)

Answer 10

5HT2A receptor antagonist and partial D2 agonist

partial agonist-> decrease DA in mesolimbic, increase in mesocortical

-treats negative sx without exacerbating positive sx

no weight gain, motor side effects, or prolactin elevation

atypical antipsychotic

Question 11

All atypical antipsychotics

Answer 11

• 5HT2A blocker to avoid extrapyramidal symptoms

- newer drugs