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- Y6 Cardiovascular > Atrial Fibrillation/Flutter > Flashcards

Atrial Fibrillation/Flutter Flashcards

1
Q

What is atrial fibrillation? What happens to the cardiac output?

A

A supraventricular tachyarrhythmia with chaotic, irregular atrial rhythm of rate 300-600bpm. AV node response intermittently so there is an irregular ventricular rhythm. CO drops by 10-20% because the ventricles are not being properly primed by the atria.

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2
Q

How common is AF?

A
  • AF - 9% of elderly >80yrs affected
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3
Q

What is shown here?

A

Atrial fibrillation

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4
Q

What is the main risk associated with atrial fibrillation? What is done to prevent this and how does this affect treatment regime?

A

Embolic stroke

Anticoagulation reduces the risk from 4% to 1% - DOACs are recommended by NICE e.g. apixaban, dabigatran, edoxaban, rivaroxaban. Warfarin is second line.

Cardioversion therapy can only be done if AF started <48h ago as left atrial appendage (LAA) thrombus may form so patient must have _>_3 weeks anticoagulation before DCC.

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5
Q

What are the causes of AF? What does “lone AF” mean?

A
  • Age
  • Coronary artery disease
  • Cardiac disease e.g. heart failure, hypertension, ischaemic heart disease, valve disease, hx arrhythmias
  • Stroke/TIA
  • OSA
  • Obesity
  • Alcohol use
  • Previous cardiothoracic intervention
  • Diabetes
  • Obesity
  • Hyperthyroidism
  • Athletic levels of physical activity (limited data)

Lone AF = no cause found

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6
Q

What are the presenting clinical features of AF?

A
  • Asymptomatic in up to 87%
  • Palpitations - on rest or activity
  • Irregular pulse
  • Dyspnoea
  • Fatigue/lightheadedness
  • Anxiety
  • Polyuria - due to tachycardia induced diuresis and natriuresis

AF may present with complications of emboli e.g. stroke, or with heart failure signs.

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7
Q

What is the difference between atrial flutter and fibrillation in simple terms?

A
  • In atrial fibrillation, the atria beat irregularly and the electrical impulses are chaotic. ECG shows fibrillatory waves of varying shapes, amplitudes, and timing associated with an irregularly irregular ventricular response when atrioventricular (AV) conduction is intact.
  • In atrial flutter, the atria beat regularly, but faster than usual and more often than the ventricles, so you may have 2 /3/4 atrial beats to every one ventricular beat. The electrical impulses are organized.
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8
Q

How are atrial flutter and fibrillation related?

A

One may turn into the other

They are also treated similarly - but DC cardioversion is preferred over pharmacological cardioversion in atrial flutter.

  • If rate control is difficult in atrial flutter then IV amiodarone may be used
  • Recurrence in atrial flutter is also high so radiofrequency ablation may be used for long-term management.
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9
Q

How do you diagnose AF? What other investigations should be done?

A

New onset atrial fibrillation

  • ECG - no discernable or distinct P wave activity, irregularly irregular ventricular rate

Other:

  • FBC - for anaemia or infection trigger
  • Clotting profile - baseline for anticoag tx
  • Renal function - U&E, Cr, exclude hypo/hyper K, hypo Mg and CKD triggers
  • TFTs
  • CXR - lung pathology cause
  • TTE - LV size and function, valvular disease
  • Depending on PC: troponin, ABG, CRP, LFTs, ESR, TOE, Holter monitor, CT angio, brain CT/MRI, CTPA
  • Serum electrolytes, cardiac biomarkers, TFTs, CXR, echo (transthoracic and transoesophageal)
  • Other: exercise stress test
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10
Q

How do you manage new onset atrial fibrillation?

A

If haemodynamically unstable → ABCDE → DC cardioversion immediately as per per-arrest → follow with 4 weeks anticoagulation

For haemodynamically stable if:

  • < 48 hours: rate* or rhythm** control
  • ≥ 48 hours or uncertain (e.g. patient not sure when symptoms started): rate* control
    • if considered for long‑term rhythm control, delay cardioversion until they have been maintained on therapeutic anticoagulation for a minimum of 3 weeks
  • Catheter ablation - if no response to antiarrhythmics; done percutaneously via groin. Anticoagulate for 4 weeks before, during procedure and for 2 months after (or lifelong if CHA2DS2VASc _>_2)

*Rate: 1st line - use combination of 2 if one does not suffice

  • BB (e.g. atenolol) OR
  • CCB (e.g. diltiazem) OR
  • Digoxin - not first line anymore as less effective; good if coexistent HF

**Rhythm: i.e. chemical cardioversion

  • BB (e.g. sotalol) OR
  • Dronedarone - 2nd line, following cardioversion
  • Amiodarone - in coexisting HF
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11
Q

What are the signs of haemodynamic instability in AF?

A
  • Hypotension (systolic <90mmHg)
  • Chest pain or MI on ECG
  • Reduced GCS or syncope
  • Heart failure signs
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12
Q

If using warfarin as anticoagulation in AF, what is the target INR range?

A

INR 2-3

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13
Q

What are the complications of catheter ablation in AF?

A
  • cardiac tamponade
  • stroke
  • pulmonary vein stenosis
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14
Q

How successful is catheter ablation at getting rid of AF?

A

50% experience recurrence within 3 months but this often resolves spontaneously

After 3yrs 55% remain in sinus rhythm

If multiple procedures 80% remain in sinus rhythm

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15
Q

What can palpitations post-op signify?

A

Post-operative atrial fibrillation - common

May be self-limiting but increases risk of :

  • haemodynamic derangements
  • postoperative stroke
  • perioperative MI
  • ventricular arrhythmias
  • heart failure

The AF may be new, post-MI which was silent, or long standing but now no longer rate controlled.

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16
Q

Which rate controlling medication should be used with caution in certain conditions?

A
  1. Beta blcokers - use with caution in COPD
  2. CCB - preferred if chronic lung disease is present but contra indicated in HF
  3. Digoxin is a cardiac glycoside - improves cardiac output so used in HF, contraindicated in those who exercise a lot
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17
Q

What is the difference between paroxysmal and persistent AF?

A

Paroxysmal - terminates spontaneously within 7 days of onset

Persistent - sustained beyond 7 days

18
Q

Which score should be calculated to work out need for anticoagulation in AF?

A

CHADS2Vasc

ORBIT is used to calculate bleeding risk

19
Q

What is the acronym for assessing embolic stroke risk/need for anticoagulation?

A

CHA2DS2-VASc

  • C- congestive heart failure/LV dysfunction
  • H- hypertension
  • A - Age 65-74y (1) Age >74y (2)
  • D - Diabetes
  • S - previous Stroke/TIA/thromboembolism(2)
  • VA- Vascular disease (MI, PVD, atherosclerosis)
  • S C - Sex Category (1 if female with one of above)

Anticoagulate if score is 2 or more (2.2% stroke rate per year). Consider if score is 1.

20
Q

What do CHA2DS2VASc scores indicate in terms of risk?

A
21
Q

What are the components of the ORBIT score for bleeding risk?

A
  • Older age - _>_75yrs → 1 point
  • Reduced Hb (<12g/dL F, <13mg/dL M), Hct (<36% F, <40% M) or anaemia→ 2 points
  • Bleeding history → 2 points
  • Insufficient renal function eGFR <60mg/dL → 1 point
  • Treatment with antiplatelets → 1 point

Low risk 0-2

Intermediate risk = 3

High risk = _>_4

NB: HASBLED is less commonly used now but consists of (1 point for each):

  • HTN
  • Abnormal renal+/- liver function
  • Stroke
  • Bleeding history
  • Labile INR
  • Elderly _>_65yrs
  • Drugs or alcohol concomitant

Low risk 0-1

Intermediate risk 2

High risk _>_3

22
Q

In the instance of stroke being the first sign of AF, when should you start anticoagulation?

A

Exclude haemorrhage first

Commence anticoagulation (DOAC or warfarin) 2 weeks after - give antiplatelets in the intervening period; delay anticoag if the cerebral infarction was large

23
Q

What are DOACs? Give examples and precautions that should be taken.

A

NOACs = direct oral anticoagulants e.g. rivaroxaban, dabigatran, apixaban, edoxaban.

  • NOACS - don’t require monitoring of anticoagulant activity
  • NOACS - must be used with caution in patients with renal impairment and a dose adjustment may be necessary.
24
Q

How is DC cardioversion carried out?

A
  • Start anticoagulation with LMWH (e.g. enoxaparin) pre-cardioversion; later transition to DOAC
  • Make sure patient is fasted state to avoid aspiration
  • Call anaesthetics to sedate patient with short-acting general anaesthetic
  • Senior support
  • Record ECG rhythm strip during and immediately after the shock is delivered
  • Monitor BP and oximetry during the procedure
  • If initial attempts fail then ensure good skin-to-electrode contact with the pads in the anteroposterior position
25
Q

What is the goal of rate control therapy?

A

Symptom control → if not controlled by this alone then add rhythm control

AV node blocking drugs are used like BB other than sotalol e.g. metoprolol, esmolol or carvedilol OR CCB which is rate-limiting like diltiazem or verapamil. These are good for reducing sympathetic tone.

26
Q

How is chemical cardioversion carried out?

A
  • Need to anticoagulate as for DC cardioversion
  • Monitoring is set up
  • Flecainide OR amiodarone (amiodarone better if there is structural heart disease) is then given orally or IV

Chemical cardioversion may be used in preference to DC in those who have WPW syndrome.

Flecainide is a class 1C anti-arrhythmic and should be co-prescribed alongside AV blocking drug like CCB/BB to prevent accelerated ventricular response

27
Q

What are the complications of atrial fibrillation?

A
  • Acute stroke - consult neurologist
  • MI - due to fast ventricular rate and increased myocardial demand
  • CCF
  • BB exacerbation or airway disease
  • Medication-related bradycardia/hypotension/HF/ pro-arrhythmia/throid dysfunction/pulmonary toxicity - discontinuation of drugs/lower dosage.
28
Q

What is the prognosis of AF?

A

Depends on precipitating event, underlying cardiac status and risk of thromboembolism.

25% of people with persistent AF progress to more sustained AF in 1.5years.

May have a 30% higher risk of cardiovascular events.

Need to monitor closely.

29
Q

Define atrial flutter.

A

A reentrant atrial tachycardia with atrial rates usually above 250 bpm up to 320 bpm.

It results from organised electrical activity in which large areas of the atrium take part in the reentrant circuit. (NB: in atrial fibrillation several small parts of the atria have disorganised electrical activity)

30
Q

What are the atrial and ventricular rates in atrial flutter?

A

250-320bpm atrial

120 to 260bpm ventricular

31
Q

What is shown on this ECG?

A

Atrial flutter - negatively directed saw-tooth pattern of atrial deflections on ECG, most prominent in II, III and aVF and V1

32
Q

How common is atrial flutter?

A

5/100,000 in people <50yrs and x100 higher in those >80yrs

Atrial flutter - 2.5:1 M:F

33
Q

What are the risk factors for atrial flutter?

A
  • Increasing age
  • Valvular dysfunction
  • Atrial septal defects
  • Atrial dilation
  • Recent cardiac or thoracic procedures
  • Surgical or post-ablation scarring of atria
  • Heart failure
  • Hyperthyroidism
  • COPD
  • Asthma
  • Pneumonia
  • Anti-arrhythmic use for AF (commonly 1c flecainide or propafenone)
  • In 60% it occurs due to an acute medical illness and will resolve when this is treated.
34
Q

What are the clinical features of atrial flutter?

A
  • Palpitations
  • Dyspnoea
  • Fatigue
  • Light-headedness
  • Chest discomfort
  • Altered consciousness
  • Polyuria
  • Exercise intolerance
  • Worsening symptoms of heart failure
  • Features of an embolic event

Uncommonly - JVP pulsations or cannon waves, chest pain, dyspnoea, syncope, hypotension, embolic event or MI

35
Q

How do you diagnose atrial flutter?

A
  • ECG
    • if 2:1 block then diagnosis may be unclear → use vagal manoeuvres or IV adenosine (slow AV node and blocks QRS to reveal associated P waves)
      • Consider Holter monitor if episodes are sporadic
    • 2:1 block = 150bpm
    • 3:1 block = 100bpm
    • 4:1 block = 75bpm

Other:

  • FBC
  • Renal function and electrolytes
  • TFTs
  • Troponin - if MI suspected
  • Digitalis levels e.g. if on digoxin
  • CXR
  • TTE - atrial and ventricular function, valvular and pericardial disease
  • Consider based on PC: D-dimer, exercise tolerance testing, MI testing, CT
36
Q

How do you manage atrial flutter?

A

If haemodynamically unstable → ABCDE → DC cardioversion (max 3 shocks of 70-120J)

If haemodynamically stable: same as AF but medication may be less effective, whereas cardioversion is more effective:

  • <48hrs - rate control or rhythm control
  • >48hrs or uncertain - rate control → if ineffective then TTE then DC cardioversion
  • Same anticoagulation regimen

Digoxin may be used as an option for rate control and may convert the atrial flutter to AF.

37
Q

What is haemodynamically unstable atrial flutter?

A
  • Shock
  • Syncope
  • MI
  • Acute, severe HF
38
Q

What are the complications of atrial flutter? How do you manage them?

A
  • BB exacerbation or airway disease
  • myocardial ischamia (from poor rate control)
  • stroke
  • medication-related bradycardia/hypotension/HF/ pro-arrhythmia/thyroid dysfunction*/pulmonary toxicity - discontinuation of drugs/lower dosage.

*amiodarone contains iodine

39
Q

What is the prognosis with atrial flutter?

A

60% of cases occur in the setting of an acute process and are usually reversed without chronic therapy.

Thromboembolic risk depends on risk factors.

Chronic atrial flutter which is unresponsive to cardioversion/ablation is harder to control with anti-arrhythmics than fibrillation.

40
Q

What is DC cardioversion synchronised to?

A

To the QRS complex

- Y6 Cardiovascular (47 decks)

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