Atrial Fibrillation Flashcards

or atrial flutter

1
Q

Explain to me what happens in atrial fibrillation

A

Electrical impulses are generated at sites other than the SA Node in the atria. these sites are called ectopic sites. commonly found at base of pulmonary vessels.

This results in random fibrillations of the atria, not all are contractions.

Because of refractory properties of AV Node, not all contractoins of atria pass through.

So it seems the atria and ventricles are contracting at random intervals to each other.

(youtube vid)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Define atrial fibrillation

A

DEFINITION: characterised by rapid, chaotic and ineffective atrial electrical conduction. Often subdivided into:

Permanent

Persistent

Paroxysmal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What a re the 3 types of atrial fibrillation?

A

Paroxysmal AF – irregular pulse that occurs sometimes and then stops. AFib stops by itself and the heart returns to normal rhythm. Recurrent episodes that stop on their own in less than 7 days

episodes lasting longer than 30 seconds but less than 7 days (often less than 48 hours) that are self-terminating and recurrent.

Persistent AF – AFib that does not stop by itself. Needs cardioversion. Recurrent episodes that last more than 7 days.

Permanent AF) – AFib that cannot be corrected by cardioversion. long-term episode

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Describe HR in atrial fibrillation?

A

Can be slow; less than 60 bpm

Or fast; more than 100 bpm

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Explain the aetiology and risk factors of atrial fibrillation

A

There may be no identifiable cause

Secondary causes lead to an abnormal atrial electrical pathway that results in AF

Systemic Causes;
Thyrotoxicosis 
Hypertension 
Pneumonia 
Alcohol 
Heart Causes ;
Mitral valve disease  
Ischaemic heart disease  
Rheumatic heart disease  
Cardiomyopathy 
Pericarditis 
Sick sinus syndrome 
Atrial myxoma 

Lung Causes;
Bronchial carcinoma
PE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Summarise the epidemiology of atrial fibrillation

A

VERY COMMON in the elderly

Present in 5% of those > 65 years

May be paroxysmal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Recognise the presenting symptoms of atrial fibrillation

A

Often ASYMPTOMATIC

Palpitations 
Syncope (if low output)  
SOB
Chest pain
--fatigue
Symptoms of the cause of AF
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the most common arrhythmia?

A

AF!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are the signs of atrial fibrillation on physical examination?

A

Irregularly irregular pulse

Difference in apical beat and radial pulse

Check for signs of thyroid disease and valvular disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Name appropriate investigations for AF?

A

ECG
Bloods
Echocardiogram

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What would investigations in AF show?

A

ECG;
Undulating/Uneven baseline with absent p waves
Irregular intervals between QRS complexes
Atrial flutter = saw-tooth

Bloods; 
Cardiac enzymes  
TFT 
Lipid profile  
U&Es, Mg2+ and Ca2+ 

Because there is increased risk of digoxin toxicity with hypokalaemia, hypomagnesaemia and hypercalcaemia

Echocardiogram 
May show: 
Mitral valve disease  
Left atrial dilatation 
Left ventricular dysfunction  
Structural abnormalities
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the difference between atrial fibrillation and atrial flutter?

A

They are both abnormal heart rhythms. … In atrial fibrillation, the atria beat irregularly. In atrial flutter, the atria beat regularly, but faster than usual and more often than the ventricles, so you may have four atrial beats to every one ventricular beat.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Name 4 cardiac enzymes.

Why do we look at cardiac enzymes in investigation for atrial fibrillation?

A

Troponin, Creatine kinase, Myoglobin, Lactate dehydrogenase

Atrial fibrillation confers a high risk of events i.e. stroke, HF and mortality.

Troponin is involved in myocyte contractility, elevated levels can foreshadow upcoming cardiovascular events.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Give a brief overview of the management plan for atrial fibrillation

A

First and foremost, try to treat any reversible causes (e.g. thyrotoxicosis, chest infection)

There are TWO main components to AF management:

  1. RHYTHM CONTROL; involves cardioversion
    1b. RATE CONTROL; involves drugs

Then;
2. Manage stroke risk - anticoagualtion

last resort: ablation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

In the management plan for atrial fibrillation what does rhythm control involve?

A
  1. If > 48 hrs since onset of AF;
    - Anticoagulate for 6 weeks ideally (updt 2021) before attempting cardioversion

1a. If < 48 hrs since onset of AF
- Direct Current cardioversion (2 x 100 J, 1 x 200 J)
- Chemical cardioversion: flecainide or amiodarone

- NOTE: flecainide is contraindicated if there is a history of ischaemic heart disease   2. Prophylaxis against AF;
Sotalol - B blocker
Amiodarone  - antiarrhytmic (class 3)
Flecainide - antiarrhythmic (class 1c)
Consider pill-in-the-pocket (single dose of a cardioverting drug (e.g. flecainide) for patients with paroxysmal AF) strategy for suitable patients  

Prolonged/ unresponsive to rounds of cardioversion and meds:

  1. Ablation (of bundles leading to AVN)
    - should be followed by pacing ; pacemaker placement
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

In the management plan for atrial fibrillation what does rate control involve?

A

Used in Chronic (Permanent) AF

Control ventricular rate with - in order:
Beta-blockers - metoprolol, propranolol
Digoxin
Verapamil

Aim for ventricular rate ~ 90 bpm

17
Q

What is the MOA of digoxin?

A

It is a cardiac glycoside. these drugs work by;

Increasing the output force of the heart and decrease its rate of contractions by acting on the cellular sodium-potassium ATPase pump

18
Q

What is the MOA of verapamil?

A

Verapamil’s mechanism in all cases is to block voltage-dependent calcium channels.

Calcium channel blockers are considered class 4 antiarrhythmic agents.

Since calcium channels are especially concentrated in the SA & AV nodes, these agents can be used to decrease impulse conduction through the AV node, thus protecting the ventricles from atrial tachyarrhythmias.

19
Q

Which drugs are used to in stroke prophylaxis in AF?

Which score is used to determine risk? Explain it.

A

Offer anticoagulation with a direct‑acting oral anticoagulant DOAC to people with atrial fibrillation and a CHA2DS2‑VASc score of 2 or above, taking into account the risk of bleeding. Apixaban, dabigatran, edoxaban

This is based on the CHADS-Vasc Score
HAS BLED score

Risk factors include:

Congestive HF
Hypertension 
Age > 75 yrs  
Diabetes
Stroke, TIA or Previous thromboembolic event

Vascular ,Valvular disease
Age 65-74
Sex; female increased risk

1 point for each but 2 points for previouse stroke and age over 75.

20
Q

Identify the possible complications of atrial fibrillation

A

THROMBOEMBOLISM

Embolic stroke risk of 4% per year

Risk is increased with left atrial enlargement or left ventricular dysfunction

Worsening of existing heart failure

21
Q

Summarise the prognosis for patients with atrial fibrillation

A

permanent AF doesnt return to sinus rhytym

22
Q

How does the number of ectopic sites on the atria influence ECG results with atrial fibrillation?

A

Influences how undulating the baseline is! More ectopic sites = flatter baseline

23
Q

How can AFs cause stroke?

A

Due to reduced atrial emptying, stagnation of blood in atria can lead to clot formation which can lead to stroke.

24
Q

What does CHADSVASC tell you?

A

stroke risk PER YEAR

if you want lifetime risk -> how many more years to life expectancy eg 80 -> so then x by cahdscvacs risk

25
Q

Indications for rate over rhythm control?

A

see ALS algorithm but if pt:

  • Presents within 48hrs
  • 4 adverse signs on bls; shock, etc
26
Q

which is a non viable treatment in atrial flutter?

A

pacemaker

27
Q

when we say rhythm control what do we mean?

A

these drugs can restore the rhythm eg bring about p waves and qrs complexes either in 1:1 ratio or whatever.

they are unlikely to slow it so will still be fast.

example is fleicanide

28
Q

Rate comtrol in af is given?

A

IV