Atopic Dermatitis Flashcards
What is the atopic triad?
Atopic dermatitis, asthma, and rhinitis.
Atopic dermatitis affects approximately what percent of children?
10%-30%
Atopic dermatitis affects approximately what percent of adults?
2%-10%
In the United States atopic dermatitis affects —-million individuals.
18
Approximately—-% of atopic dermatitis cases begin before the child is —-months old, —% occur within the first year, and —-% begin before the child turns —-years old. As many as —-% of patients will undergo spontaneous remission before they reach adolescence.
45,6,60,85,5,70
As of 2002 direct costs of atopic dermatitis in the United States were approximately…
900 million per year.
What are the two risk factors consistently associated with the development of atopic dermatitis?
Family history of atopic disease and loss of function mutations in the filaggrin gene.
What percent of patients with atopic dermatitis have family history of the disease?
70%
What are cytokines?
Small proteins that mediate cell to cell communication and thus play a role in the regulation and duration of immune responses.
———-can contribute to chronic skin dryness, increased exposure to allergens, increased skin ph, and over stimulated immune responses.
FLG mutations.
——— is a key tight junction adhesive protein.
Claudin-1
The immune system consists of ——- immunity and ——–acquired immunity.
Innate acquired.
TLR stands for…
Toll like receptors which recognize the molecule patterns of pathogens as distinct from a persons own cells.
TSLP stands for….
Thymic stromal lymphoietin
What is cAMP?
An intracellular second messenger, that keep intracellular pathways in check.
