Ativan (Lorazepam)

Question 1

Ativan (Lorazepam) class

Answer 1

Benzodiazepine

Question 2

Ativan (Lorazepam) MOA

Answer 2

Agonist action on benzodiazepine receptor binding sites on the GABAa receptor throughout CNS. Increases affinity of GABA therefore increasing the Cl channel opening, hyperpolarization.

Question 3

Ativan (Lorazepam) dosage

Answer 3

IV: 1-4 mg

Question 4

Ativan (Lorazepam) characteristics

Answer 4

O:1-2 min

P: 20-30 min

D: 6-10 hrs

H/L: 10-22 hrs

Question 5

Ativan (Lorazepam) E/M

Answer 5

M: hepatic

E: 80% renal

Question 6

Ativan (Lorazepam) considerations

Answer 6

Derived from oxazepam 1971.

Effective in limiting incidence of emergence reactions after adm of Ketamine

C/I: acute porphyrias, Hx of alcohol or substance abuse, elderly, glaucoma, & suicidal thoughts