ATI Deck

Question 1

What administration considerations apply to methotrexate?

Answer 1

Available: oral, IV, IM, preservative-free intrathecal form

For: high-dose cancer therapy

Antidote: Leucovorin (form of folic acid)

Given w/ or w/out food

IV form is not compatible with other drugs

Question 2

What administration considerations apply to cytarabine?

Answer 2

Available: Sub-Q, IV, intrathecal use

Give: Sub-Q form every 1-4 weeks, intrathecal form 4 consecutive days/ dose every 4 days

Decrease normal dose for renal impairment

Question 3

What administration considerations apply to mercaptopurine?

Answer 3

Available: oral

Give: does once daily w/ or w/out food

Base dose on client weight

Question 4

What administration considerations apply to cyclophosphamide?

Answer 4

Available: oral, IV

Give: oral w/ out food for best absorption

Food causes nausea & vomiting

Question 5

What administration considerations apply to carmustine?

Answer 5

Available: topical, IV

IV infused every 6 weeks & dose is based on weight

Oral a wafer is placed into brain surface after tumor removal

Question 6

What administration considerations apply to crisplatin?

Answer 6

Available: IV

Base dose on client weight

Don’t use aluminum containing equipment

Wear gloves when preparing solution; flush area w/ water if solution touches skin

Question 7

What administration considerations apply to doxorubicin?

Answer 7

Available: IV (Adriamycin), IV infusion (Doxil)

Wear gloves w/ solution prep; flush skin if contact w/ solution is made

Prepare form for client

Dose should by body size & cancer type

Slow IV rate for red streaking along vein or skin flushing

Question 8

What administration considerations apply to vincristine?

Answer 8

Available: IV

Dose should be based on weight & decreased w/ liver impairment

Avoid contact with eyes— causes corneal damage

Admin directly into tubing & infuse IV fluid over at least a minute

Question 9

What administration considerations apply to paclitaxel?

Answer 9

Available: 2 IV forms- Taxol (solvent system); requires pre-treatment w/ antihistamine, corticosteroid, histamine2-receptor blocker 30 min prior to infusion; non-PVC tubing & IV bag is needed; infuse over 3 hrs using inline IV filter

Abraxane- no pretreatment or special equipment; dissolve in vial; infuse over 30 min w/out inline IV filter

Paclitaxel is infused every 2-3 weeks

Question 10

What administration considerations apply to topotecan?

Answer 10

Available: IV

Base dose on weight; adjust for renal impairment

Infused over 30 min for 5 consecutive days; repeat 4x w/ 16 day rest periods in between

Question 11

What administration considerations apply to flutamide?

Answer 11

Available: oral

Admin 3x daily

Begin when GnRH drug is started

Question 12

What administration considerations apply to tamoxifen?

Answer 12

Available: oral

Admin 1-2x daily

Question 13

What administration considerations apply to anastrozole?

Answer 13

Available: oral ONLY

Give: 1x daily on empty stomach; 1 hr before or 2 hr after

Take sometime each day

Question 14

What administration considerations apply to trastuzumab?

Answer 14

Available: IV ONLY

Infuse weekly & base dose on weight; begins w/ large loading dose

DO NOT mix w/ dextrose solutions

Question 15

What administrations apply to interferon alfa-2a, interferon alfa-2b?

Answer 15

Available: Sub-Q, IM, IV

Give: prescribed biologic response modifier; verify doses (usually in Million units(MU))

Admin route & amount depends on disorder

Inject diluent into vial & gently roll until clear before withdrawing

Question 16

What administration considers actions apply to imatinib?

Answer 16

Available: oral ONLY

Give: w/ 8oz of water & meal

Dose depends on disease treated and CML phase

Question 17

What administration considerations apply to enfuvirtide?

Answer 17

Available: Sub-Q ONLY

Inject sterile water to reconstitute, gently roll, & let sit until completely clear

Refrigerate unused portion; allow to warm to room temp before use

Admin 2x daily into anterior thigh, upper arm, abdomen

Question 18

What administration considerations apply to maraviroc?

Answer 18

Available: oral ONLY

Give: w/ or w/ out food

Combine w/ other HIV drugs

Dosage range: 150-600 mg; 2x daily dependent on other taken drugs & CYP3A4 inhibitors/inducers

Question 19

What considerations apply to zidovudine?

Answer 19

Available: oral, IV

Given to pregnant: oral- 5x daily from 14 weeks gestation until delivery; during delivery, until cord is clamped

Other clients: oral- 2-3x daily; no food regard

Question 20

What administration considerations apply to delavirdine?

Answer 20

Available: oral (tabs)

Take 3x daily

Can dissolve in 3+ oz of water to make suspension

DO NOT take q/ antacids

Another NNRTI: efavirenz (Sustiva) taken 1x daily on empty stomach

Question 21

What administration considerations apply to raltegravir?

Answer 21

Available: oral ONLY

MUST combine w/ other HIV drugs

Question 22

What administration considerations apply to ritonavir?

Answer 22

Available: Oral

Take 2x daily w/ food or snack for best absorption