atherosclerosis Flashcards

1
Q

promotes production of nitric oxide

A

normal and constant shear and pressure

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2
Q

low shear can promote _____

A

artherosclerosis

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3
Q

normal shear stimulates ______

A

nitric oxide production

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4
Q

nitric oxide purpose

A

vasodilator/ helps regulate BP

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5
Q

how does vascular branching promote atherosclerosis?

A

disrupts laminar flow resulting in areas of low shear

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6
Q

most common sites of atherosclerosis

A
abdominal aorta
coronary arteries
thoracic aorta
femoral and popliteal arteries
carotid arteries
vertebral arteries
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7
Q

promotes aneurysm formation and rupture

A

High wall tension

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8
Q

Law of Laplace

A

Tension= pressure x radius / wall thickness

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9
Q

Tension is increased by _____

A

pressure and radius

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10
Q

Tension is decreased by _____

A

wall thickness

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11
Q

large arteries have _____ walls compared to veins of similar size

A

thicker

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12
Q

Stiffening of the arteries (aging) increases_____

A

systolic pressure

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13
Q

Stiffening of the arteries decreases _______

A

diastolic pressure/flow

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14
Q

shear stress is highest in _____

A

arterial walls

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15
Q

cross sectional area is highest in ______

A

capillaries

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16
Q

flow velocity is lowest in ________

A

capillaries

17
Q

Flow velocity is highest in

A

large arteries and veins with small cross sectional area

18
Q

hyperglycemia and dyslipidemia: contributes to atherosclerosis risk

A

Diabetes

19
Q

arterioles are the sites of greatest ______

A

resistance

20
Q

MAP drops lowest at the _____

A

arterioles

21
Q

what happens to pressure when arterioles are constricted?

A

Artery pressure goes up

capillary pressure goes down