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CPR II Block 2 > Asthma Pharmacology > Flashcards

Asthma Pharmacology Flashcards

1
Q

Short Acting Beta Agonists (5)

A 
Albuterol
Terbutaline
Metaproterenol
Pirbuterol
Levalbuterol
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2
Q

Long Acting Beta Agonists (5)

A 
Formoterol
Salmeterol
Indacaterol
Vilanterol
Olodaterol
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3
Q

Anticholinergic Drugs (4)

A

Atropine
Ipratropium
Tiotropium
Aclidinium

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4
Q

Theophylline

Drug Class and Actions (2), MOA, Contraindications (3)

A

Methylxanthine

Bronchodilation
Prophylactic suppression of airway stimuli

PDE5 Inhibitor

Peptic Ulcers
Seizures
Cardiac Arrhythmias

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5
Q

Inhaled Corticosteroids (7)

A 
Beclomethasone
Budesonide
Ciclesonide
Flunisolide
Fluticasone
Mometasone
Triamcinolone
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6
Q

Prednisone

Class, MOA, Indication, Cautions (2)

A

Oral corticosteroids

Decreases transcription of inflammatory genes

1st line for persistent asthma

Cushing’s Syndrome
Hyperglycemia

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7
Q

Montelukast

MOA, Indications (2) and Limitation

A

Blocks CysLT1 receptors to inhibit LTD4

Treats allergies and prevents asthma attacks

Oral delivery so not used for reversal of acute bronchospasm

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8
Q

Zafirlukast

MOA, Indication and Complication

A

Blocks CysLT1 to inhibit LTD4/LTE4

Prophylactic treatment of chronic asthma

Hepatotoxic

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9
Q

Zileuton

MOA, Indication and Caution

A

LOX inhibitor that blocks LTB4/LTC4/LTD4/LTE4

Prophylactic treatment of chronic asthma

Not recommended in liver disease with enzymes 3x the normal limit

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10
Q

Omalizumab

MOA, Indications (2) and Caution

A

Monoclonal Ab to IgE

Used for moderate-severe asthma with positive allergen testing
Chronic idiopathic urticaria

Can cause Anaphylaxis

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11
Q

Asthma/COPD Crossover Triple Therapy

A

Long acting beta agonist
Long acting muscarinic antagonist
Inhaled corticosteroid

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12
Q

SABA

Indications (4), Adverse (3)

A

Acute bronchospasm
COPD Exacerbation
Bronchitis
Bronchiolitis

Paradoxical bronchospasm
Tachycardia
Heart Palpitations

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13
Q

Terbutaline Unique Characteristics (2)

A

Only injectable SABA (subcutaneous)

Sulfa drug

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14
Q

LABA

Use (2) and Adverse Effects (2)

A

Long term maintenance of asthma/COPD
Used concomitantly with other long term drugs (ICS)

Increased risk of asthma death and hospitalization

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15
Q

Muscarinic Antagonists

Uses (2)

A

Asthma/COPD maintenance
(Ipratropium, Tiotropium and Aclidinium)

Atropine only for life threatening muscarinic situations
(only 2-3 mg in Coronary A DZ patients)

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16
Q

Inhaled Corticosteroids

MOA (2), Uses (3), Contraindications

A

Decreases transcription of inflammatory genes
Most effective anti-inflammatory asthma controllers

Exercise induced asthma
1st line for persistent asthma
Prevention of airway remodeling

Status asthmaticus
Acute bronchospasm

17
Q

Corticosteroids Associated with Adrenal Insufficiency (3)

A

Prednisone
Beclomethasone
Triamcinolone

18
Q

Coritcosteroids Associated with Candida Infections (2)

A

Fluticasone

Ciclesonide

19
Q

ICS + LABA Combination Inhalers (3)

A

Fluticasone + Salmeterol

Mometasone + Formoterol

Budesonide + Formoterol

CPR II Block 2 (5 decks)

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