asthma - other anti-inflammatory drugs

Question 1

What is the clinical use of Cromoglicate and nedocromil?

Answer 1

• now limited in asthma because of weak anti-inflammatory effects and short duration of action
• If given prophylactically it reduces intermediate / late phase asthmatic response and bronchial hyperactivity

Question 2

What ismechanism of action of Cromoglicate and nedocromil?

Answer 2

Mechanism of action unclear but may reduce histamine release from mast cells