asthma Bronchodilators- Cysteinyl leukotriene antagonists

Question 1

Zileutin actions

Answer 1

is an active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation.

Question 2

What is the function of leukotrienes?

Answer 2

bronchoconstriction
oedema
inflammation
chemoattraction

Question 3

How is Zileutin taken?

Answer 3

orally

Question 4

What receptor does Montelukast act on?

Answer 4

Montelukast is a CysLT1 antagonist

Question 5

what do the actions of Montelukast cause? (whats the therapuetic effect)

Answer 5

It reduces the bronchoconstriction otherwise caused by the leukotriene and results in less inflammation.
It relaxes the airways

Question 6

How is Montelukast taken?

Answer 6

It is usually administered orally once a day.

Question 7

When is Montelukast used?

Answer 7

Inhibit exercise induced asthma

Less effective than salbutamol but can be used as an adjunct

Question 8

What are the side effects of Montelukast?

Answer 8

can cause GI upsets / headache