Asthma: Important Cells Flashcards
Fxn of Mast cells
start acute bronchoconstriciton rxn (IAR)
- found on surface of airways
- release mediators that causes constriction + inflammation (histamine, GF, cytokines + chemo)
Macrophage Fxn
travel to airway during asthma
- activated by IgE +Ag crosslink
- start + amplify inflammatory response via cytokines
DC fxn
APCs: present Ag to other cells + gets them activated
- activate Th to Th2 —— causes more Ig production + increase E
T cell Fxn
release cytokines that increase E recruitment, increase inflammation
Th2: activate B cells to make IgE to recruit more E
B cell rxn
convert to plasma cells when activated by Th2
— make IgE
Eosinophil Fxn
Main player: causes the changes in airway
- activated + recruited IgE + histamine
- secrete proteins that cause damage to cells + remodelling of airways (chronic inflammation things )
Neutrophil Fxn
increase # in sputum; don’t really know role in asthma
T or F: there are more inflammatory cells than structural cells
F: more structural
What are the types of structural cells
epithelial cells, endothelial, SM and fibroblasts
Fxn of Epithelial Cells
translates inhaled signals into inflammatory signals
— where inflammatory cells are chilling out
— where allergen interacts with inside
- releases thymic stromal lyphopoietin (TSLP) in response to Ag: activates DCs
DCs — release IL-5 to attract Th2 to bronchiole + activate Th to Th2
Where is the normal SoA of therapies
epithelial cells
What are cytokines
messages that help maintain + amplify chronic inflammations
— Interleukins: main bois (IL3, IL4, IL5, IL8, IL13)
What are chemokines
type of cytokines that recruit other inflammatory cells
What are leukotrienes
cytokine metabolized from AA
- along with PGs, PAF: increase mucus secretion, impair ciliary/clearing system, recruit more cells, induce leaking + edema
Ex of how TH2 activates other cells
Th2 release IL5 —- recruits E (release cytokines + leukotrienes)
Th2: also release IL13+ IL5 to activate B cells to make IgE — activate MC
