ASTHMA - GLUCCORTICOIDS Flashcards
Give the effects of gluccorticoids in asthma
They are anti inflammatory and are used primarily in chronic asthma .
They are also used to prevent exacerbation of asthma
Give the moa of glucocorticoids in asthma
1) Decrease transcription oc IL2 gene
2) Reduce formation of cytokines
3) Induce annexin 1 that reduces leukotrienes and PAF
4) Inhibit allergen induced influx of eosinophils into the lungs
5) Upregulate B2 adrenoceptors
6) Decrease mast cell production
Can resistance to steriods occur
Yes
Give examples of steroids used in asthma
Beclomethasone
Triamcinalone
Flunisolide
Fluticasone
Budenoside
Mometasone
Give two steroids used in asthma that are less lipid soluble
Mometasone and Ciclesonide
What is the main ROA of the steroids
Inahaltional
In which cases can we use oral steroids
In severe disease only
What is the disadvantage of using oral steroids
Systemic effects
Give A/E that mostly occur with wrong use of devices
Sore throat
Croaky voice
Oropharyngeal candidiasis
What duration do the steroids need to reach optimal effects
Weeks to months
Why are the A/E less with Mometasone and ciclesonide
They are less lipid soluble
Corticosteroids are more likely to cause which syndrome
Cushing syndrome
Muscarinic antagonists are rarelt used in asthma but useful in?
COPD
What Is the main moa of muscarinic antagonists inastham
1) Inhibit increase in mucus secretion by competitively inhibit acetylcholine at muscarinic receptors. This inhibits contraction of smooth muscle and reduce mucus secretion
Give sone A/E of muscarinicc antagonists
Urine retention
Tachycardia
Loss of visual accomodation
Agitation
