ANTIANGINAL DRUGS

Question 1

Give three types of drugs used to treat stable angina

Answer 1

1) Beta adrenoceptor antagonists to reduce heart rate and thus myocardial oxygen need
2) Organic nitrates
3) Calcium channel blocking drugs
4) Statins and antiplatelets

Question 2

What two drugs reduces the risk of MI

Answer 2

Asprin and MI

Question 3

Variant angina is usually treated with

Answer 3

Vasodilators such as organic nitrates abd calcium antagonists

Question 4

What is the MOA of beta adrenoreceptors antagonists in angina

Answer 4

Slow the HR and thus the metabolic demand

Question 5

Give the A/E of Organic nitrates

Answer 5

Postural hypotension
Headache
Metheomoglobinamia

Question 6

Give two examples of organic nitrate

Answer 6

Glyceryl trinitrite
Isosorbide

Question 7

What is the ROA and halflife of isosorbide

Answer 7

4hrs , Orallh

Question 8

What is one limitation of organic nitrates

Answer 8

Tolerance especially with glyceryl nitrite used transdermally

Question 9

Nicorandil is a

Answer 9

Potassium channel activator and NO donor

Question 10

What type of drugs are C/I in variant angina

Answer 10

Beta adrenoceptor blockers