Asthma Drugs

Question 0

Inhaled corticosteroids are preferred as relievers or controllers of athma?

Answer 0

Inhaled form is for long term prevention and prophylaxis (controllers) while IV corticosteroid is for reliever

Question 1

Major risk factor of asthma?

Answer 1

Atopy

Question 2

Antidote for Theophylline overdose?

Answer 2

Beta-blockers

Question 5

Beta2 selective agonist for asthma prophylaxis (not for acute relief). Potentiate corticosteroid action and increase asthma mortality when used alone. May precipitate arrhythmia

Answer 5

Salmeterol - SIMD: formoterol, cleneterol, bambuterol

Question 6

Mast cell stabilizer for asthma prophylaxis and allergies (ophthalmic, nasopharyngeal, gastrointestinal) by preventing calcium influx and stabilizing mast cells

Answer 6

Cromolyn - preventing degranulation and release of histamine, leukotrienes and other mediators

Question 7

Corticosteroid: drug of choice for asthma prophylaxis. SE: oropharyngeal prophylaxis

Answer 7

Fluticasone - inhibits phospholipase A2

Question 8

Similar drug of Theophylline used for intermittent claudication

Answer 8

Pentoxifylline

Question 10

Leukotriene antagonist that blocks cysteinyl leukotriene-1 receptor for leukotrienes C4, D4 and E4

Answer 10

Montelukast

Question 11

Condition characterized by airway inflammation and episodic reversible bronchospasm

Answer 11

Asthma

Question 12

Drugs with no bronchodilator action except:

Montelukast, Zileuton, Cromolyn, Theophylline

Answer 12

Theophylline - causes bronchodilation by inhibiting phosphodiesterase and adenosine

Question 13

Anti - IgE antibody drug for prophylaxis of severe, refractory asthma not responsive to all other drugs. Extremely expensive

Answer 13

Omalizumab - monoclonal antibody, reduces reaction to inhaled antigens

Question 14

Leukotriene synthesis inhibitor for asthma prophylaxis, exercise, antigen and aspirin induced bronchospasm. SE: elevation of liver enzymes

Answer 14

Zileuton

Question 16

Muscarinic receptor antagonist for Asthma and COPD. More effective and less toxic than beta agonists in patients with COPD

Answer 16

Ipratropium - prevents vagal-stimulated bronchoconstriction

Question 18

Corticosteroid with the lowest systemic steroid toxicity

Answer 18

Ciclesonide

Question 20

Beta 2 selective agonist used as a drug of choice for acute asthma attacks. SE: may precipitate arrhythmias in patient with concurrent COPD and heart disease

Answer 20

Albuterol/Salbutamol

Question 21

Drug for treatment of severe refractory asthma (status asthmaticus)

Answer 21

IV hydrocortisone

Question 25

Methylxanthine drug used for asthma (prophylactic against nocturnal attacks). Higher clearance in adolescents and smokers, has a narrow therapeutic window

Answer 25

Theophylline - phosphodiesterase inhibition. Adenosine receptor antagonist.