ASTHMA/COPD

Question 1

*SALMETEROL

Answer 1

- terol = beta agonist
aka Serevent Diskus
Indic: ASTHMA (stage 4,5,6)
LABA, INHALED, DPI
*black box warning, never used alone
BETA-AGONIST --> bronchodilation
RELIEVER

Question 2

*ALBUTEROL

Answer 2

• terol = beta agonist
  indic: ASTHMA stage 1, COPD stage 1
  SABA
  RELIEVER

Question 3

*TIOTROPIUM

Answer 3

-tropium = think atropine = anti-cholinergic
aka SPIRIVA
long-acting (vs ipratropium)
tx: COPD, stage 1, 2
‘great’ when used w ICS (step 3.. instead of LABA)
onset: 30 min… duraction over 24 hrs
RELIEVER

Question 4

*BUDESONIDE

Answer 4

ICS
INDIC: ASTHMA stage 2,3,4,5,6 and COPD stage 3
adrs: thrush, pneumonia
CONTROLLER

Question 5

*MONTELUKAST

Answer 5

lukast = LEUKO; T = TRIENE
LEUKOTRIENE RECEPTOR ANTAGONIST
(LTD4, LTE4 = R in LU .. constrict. so block these R.) 
aka SINGULAIR
INDIC: ashtma stage 2,3,4 (NOT COPD)
- no effect w used w food
- child 2-14 ok
- no LR, drug interactions, no ADR's

Question 6

*THEOPHYLLINE

Answer 6

INDIC: COPD stage 2
alt. to low dose ICS
*concerns about toxicity
MOA: unclear

Question 7

Relievers are

Controllers are

Answer 7

• bronchodilators (beta agonist, anti-cholin.)

- anti-inflamm. (ICS, LTRA)

Question 8

What do we use to Tx COPD?

Answer 8

beta agonist, anti-cholin. short and long acting, corticosteroids

1. albuterol, ipratropium
2. formo, tio, theo
3. ICS

Question 9

What do we use to Tx ASTHMA?

Answer 9

1. SABA
2. ICA + LTRA or Theo
3. ICS + LABA/TIO or ICS + LTRA/THEO
4. ICS + LABA
5. ICS + LABA and consider MAB
6. ICS + LABA + oral corticosteroids and consider MAB

Question 10

what is the MAB used to tx asthma called?

Answer 10

OMALIZUMAB (xolair)