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PHRM825 > Asthma and COPD Controller Medications > Flashcards

Asthma and COPD Controller Medications Flashcards

1
Q

beclomethasone drug class

A

inhaled corticosteroids (ICS)

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2
Q

beclomethasone brand name

A

QVAR

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3
Q

beclomethasone dosage form

A

RediHaler (MDI)

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4
Q

beclomethasone age groups

A

> = 5 years old

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5
Q

budesonide drug class

A

inhaled corticosteroids (ICS)

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6
Q

budesonide brand names

A

Pulmicort and Pulmicort Respules

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7
Q

Pulmicort dosage form

A

flexhaler

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8
Q

Pulmicort Respules dosage form

A

nebulizer solution

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9
Q

Pulmicort age groups

A

> = 5 years old

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10
Q

Pulmicort Respules age groups

A

0-11 year olds

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11
Q

Pulmicort Respules counseling tip

A

should use jet nebulizer and not be mixed with other nebulizer medications

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12
Q

ciclesonide drug class

A

inhaled corticosteroids (ICS)

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13
Q

ciclesonide brand name

A

Alvesco

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14
Q

ciclesonide dosage form

A

HFA

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15
Q

ciclesonide age groups

A

> = 6 years old

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16
Q

fluticasone propionate drug class

A

inhaled corticosteroids (ICS)

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17
Q

fluticasone propionate brand names

A

Flovent and ArmonAir Digihaler

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18
Q

Flovent dosage forms

A

HFA and DPI

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19
Q

ArmonAir Digihaler dosage form

A

aerosol powder inhaler (DPI)

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20
Q

Flovent age groups

A

all

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21
Q

ArmonAir Digihaler age group

A

> = 12 years old

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22
Q

fluticasone furoate drug class

A

inhaled corticosteroids (ICS)

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23
Q

fluticasone furoate brand name

A

Arnuity Ellipta

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24
Q

fluticasone furoate dosage form

A

ellipta

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25
Q

fluticasone furoate age groups

A

> =5 years old

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26
Q

mometasone drug class

A

inhaled corticosteroids (ICS)

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27
Q

mometasone brand name

A

Asmanex

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28
Q

mometasone dosage forms

A

HFA and Twisthaler

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29
Q

mometasone age groups

A

> = 5 years old

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30
Q

inhaled corticosteroids adverse effects

A

-oral thrush (candidiasis)
-cough
-dysphonia

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31
Q

ICS counseling tips

A

-patients should rinse mouth and spit after use to prevent oral thrush
-most effective long-term control therapy for asthma (improves quality of life, increases lung function, and reduces risk of exacerbations)
-may increase risk of pneumonia in patients with COPD
-titrate to lowest effective dose
-high doses increase risk for systemic side effects

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32
Q

arformoterol tartrate drug class

A

long-acting beta agonist (LABA)

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33
Q

arformoterol tartrate brand name

A

Brovana

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34
Q

arformoterol tartrate dosage form

A

nebulizer solution

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35
Q

arformoterol tartrate age group

A

> =12 years old

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36
Q

arformoterol tartrate indication

A

COPD

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37
Q

formoterol drug class

A

long-acting beta agonist (LABA)

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38
Q

formoterol brand name

A

Perforomist

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39
Q

formoterol dosage form

A

nebulizer solution

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40
Q

formoterol age group

A

> =12 years old

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41
Q

formoterol indication

A

COPD only unless used in combination with ICS

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42
Q

indacaterol drug class

A

long-acting beta agonist (LABA)

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43
Q

indacaterol brand name

A

Arcapta Neohaler

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44
Q

indacaterol dosage form

A

neohaler

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45
Q

indacaterol age group

A

> = 12 years old

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46
Q

indacaterol indication

A

COPD

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47
Q

olodaterol drug class

A

long-acting beta agonist (LABA)

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48
Q

olodaterol brand name

A

Striverdi Respimat

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49
Q

olodaterol dosage form

A

respimat

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50
Q

olodaterol age group

A

> = 12 years old

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51
Q

olodaterol indication

A

COPD

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52
Q

salmeterol drug class

A

long-acting beta agonist (LABA)

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53
Q

salmeterol brand name

A

Serevent

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54
Q

salmeterol dosage form

A

diskus

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55
Q

salmeterol age groups

A

> = 4 years old

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56
Q

LABA adverse effects

A

-tachycardia
-headache
-tremor
-hypokalemia

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57
Q

LABA boxed warnings

A

-increased risk of asthma-related death for all monotherapy (LABA should not be used alone for asthma management)
-increasing hospitalizations in pediatric and adolescent patients

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58
Q

LABA counseling tips

A

-prolonged QT seen with intentional overdoses
-not for acute symptoms
-may be helpful for exercise-induced bronchospasm
-formoterol and indacaterol capsules should not be taken orally

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59
Q

LABA pediatric consideration

A

most children <4 years old cannot provide sufficient inspiratory flow for adequate lung delivery with a DPI

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60
Q

aclidinium drug class

A

long-acting antimuscarinic (LAMA)

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61
Q

aclidinium brand name

A

Turdorza Pressair

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62
Q

aclidinium dosage form

A

DPI

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63
Q

aclidinium age group

A

> = 12 years old

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64
Q

aclidinium indication

A

COPD

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65
Q

glycopyrrolate drug class

A

long-acting antimuscarinic (LAMA)

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66
Q

glycopyrrolate brand name

A

Seebri Neohaler

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67
Q

glycopyrrolate dosage forms

A

DPI and nebulization solution

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68
Q

glycopyrrolate age group

A

> =12 years old

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69
Q

glycopyrrolate indication

A

COPD

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70
Q

revefenacin drug class

A

long-acting antimuscarinic (LAMA)

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71
Q

revefenacin brand name

A

Yupelri

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72
Q

revefenacin dosage form

A

nebulization solution

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73
Q

revefenacin age group

A

> =12 years old

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74
Q

revefenacin indication

A

COPD

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75
Q

tiotropium drug class

A

long-acting antimuscarinic (LAMA)

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76
Q

tiotropium brand name

A

Spiriva

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77
Q

tiotropium dosage forms

A

HandiHaler and Respimat

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78
Q

Spiriva HandiHaler age group

A

> = 12 years old

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79
Q

Spiriva Respimat age groups

A

> = 6 years old

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80
Q

Spiriva HandiHaler indication

A

COPD

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81
Q

tiotropium counseling tip

A

approved for use in asthma as an add-on option for children >= 12 years old

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82
Q

umeclidinium drug class

A

long-acting antimuscarinic (LAMA)

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83
Q

umeclidinium brand name

A

Incruse Ellipta

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84
Q

umeclidinium dosage form

A

DPI

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85
Q

umeclidinium age group

A

> = 12 years old

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86
Q

umeclidinium indication

A

COPD

87
Q

LAMA adverse effects

A

-dry mouth
-dizziness
-blurred vision
-upper respiratory infections
-paradoxical bronchospasms

88
Q

fluticasone/salmeterol drug class

A

ICS/LABA combination

89
Q

fluticasone/salmeterol brand names

A

Advair, AirDuo, and AirDuo Digihaler

90
Q

Advair dosage forms

A

DPI and HFA MDI

91
Q

Advair DPI age groups

A

> = 5 years old

92
Q

Advair HFA MDI age group

A

> =12 years old

93
Q

AirDuo and AirDuo Digihaler dosage form

A

Respiclick (DPI)

94
Q

AirDuo and AirDuo Digihaler age group

A

> = 12 years old

95
Q

budesonide/formoterol drug class

A

ICS/LABA combination

96
Q

budesonide/formoterol brand name

A

Symbicort

97
Q

budesonide/formoterol dosage form

A

HFA MDI

98
Q

budesonide/formoterol age groups

A

> = 5 years old

99
Q

mometasone/formoterol drug class

A

ICS/LABA combination

100
Q

mometasone/formoterol brand name

A

Dulera

101
Q

mometasone/formoterol dosage form

A

MDI

102
Q

mometasone/formoterol age group

A

> = 12 years old

103
Q

fluticasone/vilanterol drug class

A

ICS/LABA combination

104
Q

fluticasone/vilanterol brand name

A

Breo Ellipta

105
Q

fluticasone/vilanterol dosage form

A

DPI

106
Q

fluticasone/vilanterol age group

A

> = 12 years old

107
Q

ICS/LABA combination counseling tips

A

-recommend combination LABA with ICS in asthma because LABA should not be used as monotherapy
-combination products were developed to create convenient packaging and assist with patient adherence

108
Q

olodaterol/tiotropium drug class

A

LABA/LAMA combination

109
Q

olodaterol/tiotropium brand name

A

Stiolto Respimat

110
Q

olodaterol/tiotropium dosage form

A

Respimat

111
Q

olodaterol/tiotropium age group

A

> = 12 years old

112
Q

olodaterol/tiotropium indication

A

COPD

113
Q

vilanterol/umeclidinium drug class

A

LABA/LAMA combination

114
Q

vilanterol/umeclidinium brand name

A

Anoro Ellipta

115
Q

vilanterol/umeclidinium dosage form

A

Ellipta

116
Q

vilanterol/umeclidinium age group

A

> = 12 years old

117
Q

vilanterol/umeclidinium indication

A

COPD

118
Q

indacaterol/glycopyrronium drug class

A

LABA/LAMA combination

119
Q

indacaterol/glycopyrronium brand name

A

Utibron Neohaler

120
Q

indacaterol/glycopyrronium dosage form

A

Neohaler

121
Q

indacaterol/glycopyrronium age group

A

> = 12 years old

122
Q

indacaterol/glycopyrronium indication

A

COPD

123
Q

formoterol/glycopyrronium drug class

A

LABA/LAMA combination

124
Q

formoterol/glycopyrronium brand name

A

Bevespi Aerosphere

125
Q

formoterol/glycopyrronium dosage form

A

Aerosphere

126
Q

formoterol/glycopyrronium age group

A

> = 12 years old

127
Q

formoterol/glycopyrronium indication

A

COPD

128
Q

formoterol/aclidinium drug class

A

LABA/LAMA combination

129
Q

formoterol/aclidinium brand name

A

Duaklir Pressair

130
Q

formoterol/aclidinium dosage form

A

DPI

131
Q

formoterol/aclidinium age group

A

> = 12 years old

132
Q

formoterol/aclidinium indication

A

COPD

133
Q

LABA/LAMA combination counseling tip

A

not indicated for treatment of acute deteriorations

134
Q

fluticasone/umeclidinium/vilanterol drug class

A

LABA/LAMA/ICS combination

135
Q

fluticasone/umeclidinium/vilanterol brand name

A

Trelegy Ellipta

136
Q

fluticasone/umeclidinium/vilanterol dosage form

A

Ellipta

137
Q

fluticasone/umeclidinium/vilanterol age group

A

> =12 years old

138
Q

budesonide/glycopyrrolate/formoterol fumarate drug class

A

LABA/LAMA/ICS combination

139
Q

budesonide/glycopyrrolate/formoterol fumarate brand name

A

Breztri Aerosphere

140
Q

budesonide/glycopyrrolate/formoterol fumarate dosage form

A

Aerosphere

141
Q

budesonide/glycopyrrolate/formoterol fumarate age group

A

> = 12 years old

142
Q

budesonide/glycopyrrolate/formoterol fumarate indication

A

COPD

143
Q

cromolyn drug class

A

mast cell stabilizer

144
Q

cromolyn brand name

A

Intal

145
Q

cromolyn dosage form

A

nebulizer solution

146
Q

cromolyn age groups

A

all

147
Q

mast cell stabilizer adverse effects

A

-high incidence of unpleasant taste in mouth (>10%)
-rare cardiac arrhythmias
-coughing
-dyspnea
-sore throat
-nausea, vomiting, and diarrhea if absorbed systemically

148
Q

mast cell stabilizer counseling tips

A

-less effective than low-dose ICS
-prevents increase in bronchial hyperreactivity seen in allergy season

149
Q

montelukast drug class

A

leukotriene modifiers

150
Q

montelukast brand name

A

Singulair

151
Q

montelukast dosage forms

A

tablets, chewable tablets, and granule packets

152
Q

montelukast age groups

A

> = 1 year old

153
Q

montelukast counseling tips

A

-minor substrate of CYP2C8/9 and 3A4
-not for acute relief of symptoms
-boxed warning –> neuropsychiatric events

154
Q

zafirlukast drug class

A

leukotriene modifiers

155
Q

zafirlukast brand name

A

Accolate

156
Q

zafirlukast dosage form

A

tablet

157
Q

zafirlukast age groups

A

> = 5 years old

158
Q

zafirlukast counseling tips

A

-take at least 1 hour before or 2 hours after meals
-can increase INR
-major substrate and minor inhibitor of CYP2C9

159
Q

zileuton drug class

A

leukotriene modifiers

160
Q

zileuton brand name

A

Zyflo CR

161
Q

zileuton dosage forms

A

IR tablets and ER tablets

162
Q

zileuton age group

A

> = 12 years old

163
Q

zileuton counseling tips

A

-weak CYP1A2 inhibitor
-take with food

164
Q

leukotriene modifier adverse effects

A

-neuropsychiatric events (agitation, anxiety, abnormal dreams, hallucinations, depression, suicidal thinking)
-Churg-Strauss syndrome (rare)
-increased hepatic transaminases (zafirlukast and zileuton)

165
Q

leukotriene modifier counseling tips

A

-less effective than low-dose ICS and ICS/LABA in asthma
-have not been adequately trialed in COPD

166
Q

theophylline drug class

A

methylxanthines

167
Q

theophylline brand name

A

Theochron

168
Q

theophylline dosage forms

A

ER 12 hour tablets, ER 24 hour tablets, ER 24 hour capsule, and liquid solution

169
Q

theophylline indications

A

acute exacerbation and chronic management

170
Q

methylxanthine adverse effects

A

-insomnia
-gastrointestinal upset
-hyperactivity
-hypotension
-tremor

171
Q

methylxanthine dose-related toxicities

A

-tachycardia
-nausea
-vomiting
-headache
-seizures
-arrhythmias

172
Q

methylxanthine contraindications

A

-peptic ulcer disease
-arrhythmias
-seizure disorders

173
Q

methylxanthine drug interactions

A

-major substrate of CYP3A4, 1A2, and 2E1
-increases concentration –> cimetidine, erythromycin, clarithromycin, ciprofloxacin, ticlopidine
-decreases concentration –> phenobarbital, phenytoin, carbamazepine, rifampin, smoking
-PDE III inhibition is a likely cause for hypotension, tachycardia, and nausea

174
Q

omalizumab drug class

A

anti-IgE

175
Q

omalizumab brand name

A

Xolair

176
Q

omalizumab dosage forms

A

prefilled syringe and vial

177
Q

omalizumab age groups

A

> = 6 years old

178
Q

anti-IgE adverse effects

A

-headache
-injection site reactions
-arthralgias
-thrombocytopenia
-pharyngitis
-sinusitis
-upper respiratory tract infections

179
Q

anti-IgE boxed warning

A

anaphylaxis

180
Q

anti-IgE counseling tips

A

-do not give more than 150 mg per injection site
-monitor for anaphylaxis before and after injection
-FDA approved for moderate to severe persistent asthma in patients with a positive skin test or reactivity to a perennial aeroallergen and symptoms that are inadequately controlled with ICS

181
Q

mepolizumab drug class

A

anti-IL5

182
Q

mepolizumab brand name

A

Nucala

183
Q

mepolizumab dosage forms

A

auto-injector and vial

184
Q

mepolizumab age groups

A

> = 6 years old

185
Q

mepolizumab adverse effects

A

-headache
-injection site reactions
-arthralgias
-herpes zoster infection

186
Q

mepolizumab counseling tips

A

-anaphylaxis (precaution)
-available as in-clinic or at-home injection
-monitor for anaphylaxis before and after injection
-indicated for add-on maintenance treatment of patients with severe asthma with an eosinophilic phenotype

187
Q

reslizumab drug class

A

anti-IL5

188
Q

reslizumab brand name

A

Clinqair

189
Q

reslizumab dosage form

A

liquid solution

190
Q

reslizumab age group

A

> = 18 years old

191
Q

reslizumab adverse effects

A

-injection site reactions
-myalgias
-increased creatinine phosphokinase

192
Q

reslizumab boxed warning

A

anaphylaxis and malignancies

193
Q

reslizumab counseling tips

A

-monitor for anaphylaxis before and after injection
-indicated for add-on maintenance treatment of patients with severe asthma with an eosinophilic phenotype

194
Q

benralizumab drug class

A

anti-IL5

195
Q

benralizumab brand name

A

Fasenra

196
Q

benralizumab dosage forms

A

auto-injector and pre-filled syringe

197
Q

benralizumab age group

A

> = 12 years old

198
Q

benralizumab adverse effects

A

-injection site reactions
-antibody development
-headache
-pharyngitis
-fever

199
Q

benralizumab counseling tips

A

-anaphylaxis (precaution)
-available in pre-filled syringe for in-office or at-home administration
-indicated as an add-on maintenance treatment of severe asthma in adults and children >= 12 years of age with an eosinophilic phenotype
-acts on IL-5 receptors while others act on IL-5

200
Q

dupilumab drug class

A

anti-IL4/IL13

201
Q

dupilumab brand name

A

Dupixent

202
Q

dupilumab dosage form

A

injection

203
Q

dupilumab age group

A

> = 12 years old

204
Q

dupilumab adverse effects

A

-injection site reactions
-antibody development
-arthralgias
-conjunctivitis

205
Q

dupilumab counseling tips

A

-anaphylaxis (precaution)
-available in pre-filled syringe for in-office or at-home administration
-indicated as an add-on maintenance treatment in patients with moderate to severe asthma aged 12 years and older with an eosinophilic phenotype or with oral corticosteroid dependent asthma

206
Q

roflumilast drug class

A

phosphodiaesterase-4 inhibitors

207
Q

roflumilast brand name

A

Daliresp

208
Q

roflumilast dosage form

A

tablet

209
Q

roflumilast age group

A

> = 12 years old

210
Q

roflumilast indication

A

COPD

211
Q

roflumilast adverse effects

A

hemagglutinin

212
Q

roflumilast monitoring

A

liver function test and weight

213
Q

roflumilast drug interactions

A

CYP3A4 (major) and CYP1A2 (minor)

214
Q

roflumilast contraindication

A

Child-Pugh class B or C

PHRM825 (5 decks)

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