Asthma Flashcards
What is asthma?
Chronic inflammatory disorder of airways
What does asthma cause?
Causes airway hyperresponsiveness leading to wheezing, breathlessness, chest tightness, and cough
Who has a greater prevalence to asthma?
Women and African Americans have a greater prevalence
What are the tigers of asthma?
Allergens Exercise Air pollutants Occupational Factors Respiratory Infection Nose and Sinus Problems Drugs and Food Additives Gastroesophageal Reflux Disease Emotional Stress
What are the two types of allergen triggers?
Seasonal and year round
Explain the exercise trigger?
Induced or exacerbated after exercise
Pronounced with exposure to cold air
Breathing through a scarf or mask may ↓ likelihood of symptoms
What are considered air pollutants?
Cigarette or wood smoke: smoke outside.
Vehicle exhaust
Elevated ozone levels
Sulfur dioxide
What is the most common form of occupational lung disease?
Asthma
Explain occupational trigger.
Exposure to diverse agents
Arrive at work well, but experience a gradual decline
Explain respiratory trigger.
Major precipitating factor of an acute asthma attack
↑ inflammation hyperresponsiveness of the tracheobronchial system
Explain nose and sinus trigger.
Allergic rhinitis and nasal polyps
Large polyps are removed
Sinus problems are usually related to inflammation of the mucous membranes
Most of the time, asthma pt have underlining sinus problems. Making the airway worse
Explain drug triggers.
Asthma triad: nasal polyps, asthma, and sensitivity to aspiri and NSAIDs
Wheezing develops in about 2 hrs
Sensitivity to salicylates
Found insalicylates many foods, beverages, and flavorings
Explain Food triggers.
Food allergies may cause asthma symptoms
Avoidance diets:
Rare in adults
People slightly out grow food allergy
Explain Gastroesophageal Reflux Disease trigger.
Reflux of acid could be aspirated into lungs causing bronchoconstriction
Fix GI and usually fix asthma
Explain emotional triggers.
Psychological factors can worsen the disease process
Attacks can trigger panic and anxiety
Extent of affect is unknown
What is the primary pathophysiology response?
Primary response is chronic inflammation from exposure to allergens or irritants
Leading to airway hyperresponsiveness and acute airflow limitations
Inflammatory mediators cause (early-phase response). What is the early -phase response?
Vascular congestion Edema formation Production of thick, tenacious mucous Bronchial muscle spasm Thickening of airway walls
What is late-phase response?
Occurs within 4-10 hours after initial attack
Only occurs in 30-50% of patients
Can be more severe than early-phase and last for 24 hours or more
If airway inflammation is not treated or does not resolve, it may lead to irreversible lung damage
Is Wheezing is reliable to gauge severity?
No! Severe attacks may have no audible wheezing
An acute attack usually reveals signs of hypoxemia. What are the signs?
Restlessness ↑ anxiety ↑ pulse and blood pressure Pulsus paradoxus (drop in systolic BP during inspiratory cycle > 10 mm Hg) Inappropriate behavior: Confusion Acting out Not Oriented
What are the classifications of asthma?
Intermittent
Mild
Moderate
Severe
What is Status asthmaticus?
Severe, life-threatening attack unresponsive to usual treatment
Patient at risk for respiratory failure
Where full blown attack, but having extreme trouble getting under control.
What are causes of status asthmaticus?
Viral illnesses Ingestion of aspirin or other NSAIDs Environmental pollutants or allergen exposure Emotional stress Abrupt discontinuation of drug therapy Abuse of aerosol medication Ingestion of β-adrenergic blockers: Contraindication to asthma!! Blocks part of response to airway.
Clinical manifestations of status asthmaticus result from..
Increased airway resistance from edema
Mucous plugging
Bronchospasm
Respiratory acidosis
Explain status asthmaticus.
As attack severity ↑, work of breathing ↑, patient tires, and it is harder to overcome the ↑ resistance to breathing
Ultimately the patient deteriorates to hypercapnia and hypoxemia
What are complications of status asthmaticus?
Pneumothorax
Acute cor pulmonale: right sided heart failure
Drop in O2 saturation (SaO2)
Severe respiratory muscle fatigue leading to respiratory arrest
Both indicating mechanical ventilation.
What is Acute cor pulmonale?
Right sides heart failure
What is the usual result of death?
Death is usually result of respiratory arrest or cardiac failure
What are some diagnostic studies for asthma?
Detailed history and physical exam
Pulmonary function tests and Peak flow monitoring
-Withhold bronchodilators for 6-12 hours before the tests.
Chest x-ray: acute attack
ABGs: Done if they are in an acute attack Oximetry
Allergy testing
Blood levels of eosinophils
Sputum culture and sensitivity