Assignment(s) Deck

Question 1

In coordination chemistry the donor atom of a ligand is_________

Answer 1

The atom in the ligand that shares an electron pair with the metal

Question 2

The biological functions of carbonic anhydrase and alcohol dehydrogenase, respectively are________

Answer 2

Interconversion of CO2 and carbonates, and alcohols, and aldehyde

Question 3

The active sites of carboxypeptidase A contains______ and catalyzes_______

Answer 3

Zn(II); the hydrolysis of peptide bonds

Question 4

The ligand system found in hemoglobin and myoglobin is ___________

Answer 4

Porphyrin

Question 5

The binding of O2 to hemoglobin shifts from low affinity to high affinity state as____________

Answer 5

Partial pressure of O2 increases

Question 6

The amino acid side chains that acts as ligands and with high affinity for Fe3+ in transferrin are __________

Answer 6

Tyrosine, histidine, and aspartate

Question 7

Ferritins in biological systems are involved in__________

Answer 7

Storage of Fe

Question 8

Siderophores are small polydentate ligands with high affinity for iron. Their main role is to __________

Answer 8

Aid iron uptake/mobilization

Question 9

Identify the biological function of hemocyanin and the metal ion responsible for its function.

Answer 9

O2 transport and Cu

Question 10

Which one of the following is NOT the essential functions of iron in biological systems?

Answer 10

Muscle movement

Question 11

The amino acid side chains that act as ligands for the binding of Ca2+ in Calmodulin are _____________

Answer 11

Aspartate, glutamate, and peptide carbonyls

Question 12

Iron-Sulfur clusters in biological systems are involved in __________

Answer 12

Electron transfer

Question 13

A well-known naturally occurring organometallic compound is___________

Answer 13

Vitamin B12 coenzyme

Question 14

The main biological function of cytochrome-c peroxidase is _____________

Answer 14

Reduction of H2O2 to water

Question 15

Identify the biological function of cytochrome-c and the metal responsible for its function.

Answer 15

Electron transfer and Fe

Question 16

Molybdenum-containing enzymes are involved in _________.

Answer 16

Oxygen atom transfer reactions

Question 17

Superoxide dismutase contains the metal ions________.

Answer 17

Cu(II) and Zn(II)

Question 18

What is the molecular basis of the mode of action for Pt(II) chemotherapy agents?

Answer 18

Formation of a stable complex between DNA and Pt(II) resulting in the bending of DNA helix and partial unwinding

Question 19

The treatment of iron overload by chelation therapy involves sequestration of iron using __________

Answer 19

Siderophores

Question 20

Which one of the following represents the two commonly used metallic elements as imaging agents?

Answer 20

Gadolinium and technetium

Question 21

Besides the platinum family, the complexes of which d-block element are getting more importance in anticancer chemotherapy?

Answer 21

Ru (ruthenium)