Aspirin Overdose Flashcards

1
Q

What class of drug is aspirin.

A

Salicylate.

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2
Q

What is aspirin. (2)

A

It is a weak acid with poor water solubility.

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3
Q

What dose of aspirin will cause mild toxicity.

A

150mg/kg.

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4
Q

What level of aspirin is required to be fatal.

A

700mg/kg.

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5
Q

What are the early features of aspirin poisoning. (8)

A
Vomiting. 
Dehydration. 
Hyperventilation. 
Vertigo. 
Sweating. 
Tinnitus. 
Deafness.
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6
Q

What are the rarer features of aspirin overdose. (6)

A
Low GCS. 
Seizures. 
Bounding pulse. 
Low BP and heart block. 
Pulmonary oedema. 
Hyperthermia.
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7
Q

What is the acid state of a patient presenting with aspirin overdose. (2)

A

Initially present with respiratory alkalosis due to a direct stimulation of the central respiratory centres.
(They then develop a metabolic acidosis if serious).

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8
Q

What are the glucose levels of a patient with aspirin overdose.

A

Hypo or hyperglycaemia.

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9
Q

What is associated with serious aspirin overdose. (8)

A
Metabolic acidosis. 
Hyperprothrombinaemia. 
Hyperglycaemia. 
Hyperpyrexia. 
Renal failure. 
Pulmonary oedema. 
Shock.
Cerebral oedema.
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10
Q

What symptoms of aspirin overdose are common in children. (4)

A

Agitation.
Confusion.
Coma.
Fits.

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11
Q

What do you give a patient presenting with aspirin poisoning (within 1 hour).

A

Activated charcoal.

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