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PMOC LAB/LEC MIDTERM > Aspirin/ Acetone/ Acetanilide > Flashcards

Aspirin/ Acetone/ Acetanilide Flashcards

1
Q

IUPAC name of Aspirin?

A

2-acetoxybenzoic acid

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2
Q

Chemical formula of Aspirin?

A

C9H8O4

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3
Q

Give the synonyms of Aspirin

A

Acetyl salicylic acid
Acidium salicylicum
o-acetylsalicylic acid
polypiryna
salicylic acidacetate

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4
Q

Chemical Synthesis of Aspirin?

A

Ester Formation/ Esterification

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5
Q

Synthesis of Aspirin?

A

Salicylic Acid (HO-C6H4-COOH) + Acetic anhydride (CH3C=O-O-C=OCH3) –(H2SO4)——> Acetyl salicylic acid (CH3C=OOC6H4-COOH) + Acetic Acid (OHC=OCH3)

Salicylic Acid (HO-C6H4-COOH) + Acetyl chloride (CH3-C=O-Cl) —-(pyridine)—> Acetyl salicylic acid (CH3C=OOC6H4-COOH) + hydrochloric acid (HCl)

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6
Q

Physical properties of Aspirin?

A

Colorless/ white crystalline powder
odorless
Density:1.40 g/cm3
MP: 135 C/ 275 F
BP: 140 C/ 284 F
Solubility in H2O: 3mg/ml [20 C]

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7
Q

Acid Hydrolysis positive result?

A

violet

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8
Q

Base Hydrolysis positive result?

A

Clear/ colorless sol.

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9
Q

what reagent makes the enol CMPD turn violet?

A

FeCl/Ferric chloride

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10
Q

State the aspirin indications:

A

ANTI-PLATELET (40-80mg)
ANTI-INFLAMMATORY (45mg/kg)
ANALGESIC (325-650mg)
ANTIPYRETIC (325-650mg)

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11
Q

what receptor aspirin bind?

A

Arachidonic acid

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12
Q

Arachidonic Acid

A

promotes the repair and growth of skeletal muscle tissue via conversion to prostaglandin PGF2alpha during and following physical exercise

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13
Q

Release PGE2 GI mucosa for cytoprotection
INC mucus production
INC HC03
INC BLOOD FLOW

A

COX1

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14
Q

PGE2 + PGI2 => Kidney
INC GFR (filtration of kidney)
Retention of Na & H2O
roles in mediating inflammation

A

COX1 &COX2

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15
Q

PGI2 + TXA2
COX2= PGI2
promotes Cardiovascular
vasodilation
INC platelet aggregation

A

COX1 + COX2

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16
Q

Aspirin inhibits

A

COX 1, COX 2, TXA2

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17
Q

Active peptic ulcer
haemostatic disorder
hypersensitivity
asthma
kidney disease (exacerbate the condition)
Hyperuricemia or gout
Hemolytic anemia
Dengue fever
Children or adolescents w/ viral interfection

A

Aspirin contraindication

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18
Q

viral infection in the children then take an aspirin to relief the fever can cause _______

A

reye’s syndrome

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19
Q

acute ingestion of 150-200 mg/kg ASA will produce___

A

Mild intoxication

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20
Q

acute ingestion of 300-500 mg/kg ASA will produce___

A

severe intoxication

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21
Q

ingestion of more than 100 mg/kg/day, 2 or more days of ASA will produce___

A

chronic intoxication

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22
Q

Vomiting after ingestion
hyperpnea
Tinnitus & Lethargy
Mixed respiratory Alkalemia
metabolic Acidosis

A

acute toxicity of ASA

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23
Q

Rapid and shallow breathing

A

Hyperpnea

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24
Q

nonspecific confusion
dehydration and metabolic acidosis are attributed to sepsis
Pneumonia
Gastroenteritis

A

Chronic Toxicity of Aspirin

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25
Q

Treatment for ASA toxicity

A

Activated charcoal
NaHCO3(Sodium Bicarbonate)
Hemodialysis

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26
Q

Why aspirin is a better pain reliever than salicylic acid?

A

ASA is less irritating to the stomach and not bitter

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27
Q

Why do people without H/A or pain use ASA regularly as their maintenance drug?

A

ASA inb. COX1 => no TXA2 that promotes platelet aggregation
use for stroke and heart attack

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28
Q

why ASA cause methemoglobinemia?

A

ASA convert ferric to ferrous. Ferric is the responsible for O2 in RBC

29
Q

IUPAC name of Acetanilide?

A

N-phenylethanamide

30
Q

Chemical Formula of Acetanilide

A

C8H9NO

31
Q

Synonym of Acetanilide

A

acetylaminobenzene
CAN
Antifelorin
acetylaniline
N-phenylethanamide

32
Q

what is Antifelorin use and ADR

A

analgesic and antipyretic
ADR: cyanosis (blue skin)

33
Q

metabolic pathway of Antifelorin

A

phenolic metabolisim

34
Q

Synthesis of Acetanilide?

A

aniline (C6H5-N<H2) + Acetyl chloride (CH3-C=O-Cl)
—-> Acetanilide(C6H5-NH-C=O- CH3) + HCI

aniline (C6H5-N<H2) + Acetic anhydride (CH3C=O-O-C=OCH3) –(H2SO4)——> Acetanilide(C6H5-NH-C=O- CH3)+ Acetic Acid (OHC=OCH3)

35
Q

Process of synthesis of acetanilide ?

A

Acetylation

36
Q

what process makes the acetanilide purify

A

Crystallizations

37
Q

A positive result of acid hydrolysis of acetanilide

A

crystal formation (aniline)

38
Q

A positive result of bromination of acetanilide

A

white ppt upper and lower part/ clear in the middle

39
Q

A positive result of bromination of Aniline

A

yellow slimy substance at the middle

40
Q

acetanilide forms______ in bromination

A

mono brominates (as major product)
4-bromo acetanilide

41
Q

aniline forms______ in bromination

A

tri-mono brominates (as major product)
tribromoaniline

42
Q

Synonyms of acetone

A

2- propanone
Dimethyl ketone
Propanone
beta- ketopropan
Dimentyl formaldehyde

43
Q

simplest ketone

A

acetone

44
Q

physical appearance of acetone

A

colorless and flammable

45
Q

Bolling point of acetone

A

133 F/ 56.2 C

46
Q

acetone is normally present in ____ and ______

A

Blood , urine

47
Q

______produce it in larger amounts

A

Diabetic people

48
Q

people on a ________ will have more acetone in their body

A

Low fat diet

49
Q

Use of acetone

A

solvent
denaturant in alcohol
defatting prior to chemexfoliation

50
Q

A substance attracted to by ______(transmit the parasitic protozoan known to produce the often fatal disease called_______) including carbon dioxide and octenol

A

tseste files, sleeping sickness

51
Q

acetone exhibit only _____in normal use

A

slight toxicity

52
Q

Cumen process is aka_____

A

Phenol processss or hock process

53
Q

Propylene + water ==> 2-propanol
2-propanol + Oxygen ==> acetone
what synthesis process is this?

A

wacker–Hoechst process

54
Q

synthesis of ____ of Acetates

A

Dry distillation

55
Q

Acetone- butanol- ethanol fermentation developed by _____with the aid of _____ bacteria.

A

Chaim Mweizman, Clostridium acetobutylicum

56
Q

____ is no longer used due to small yields

A

Acetone- butanol- ethanol fermentation

57
Q

tollen test result of acetone

A

negative clear

58
Q

Bisulfite Addition result

A

white ppt

59
Q

acetone functional group

A

carbonyl group

60
Q

Methadone

A

potent analgesic

61
Q

naloxone

A

opioid analgesic

62
Q

Acetaphenone

A

sedative

63
Q

ketone bodies present in urine

A

Ketonuria

64
Q

acetone breath

A

ketoacidosis

65
Q

Acetone is formed when body use____instead of glucose for energy. Acetone is broken down by ____ which oxidized via _____ to yield energy.

A

fat, acetyl coa, TCA cycle

66
Q

Sodium nitroprusside and strong solution of ammonia water is a test for ?

A

presence of ketonuria

67
Q

Sodium nitroprusside and strong solution of ammonia water positive result?

A

magenta ring form at the line of contact

68
Q

Cynide nitropursside teste test aka

A

Brand test

69
Q

brand test + result

A

red purple colour

PMOC LAB/LEC MIDTERM (2 decks)

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