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PMOC LAB/LEC MIDTERM > ANTIVIRAL AGENT > Flashcards

ANTIVIRAL AGENT Flashcards

1
Q

indicated for the treatment of chronic Hepatitis B

A

Tenofovir disproxil fumarate/ tenofovir alafenamide 2008

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2
Q

brand name of Tenofovir disproxil fumarate

A

Viread

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3
Q

Brand name of Tenofovir alafenamide

A

Vemlidy

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4
Q

1st all-oral, one dose per day for Hepatitis C
other drugs harvoni, epclusa and vosei

A

Sofosbuvir 2013

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5
Q

Brand name of Sofosbuvir

A

Sovaldi

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6
Q

pre-exposure prophylaxis
reduce the risk of getting HIV I from intercourse when every day
Tenofovir disproxil fumarate and emtricitabine

A

truvada

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7
Q

Brand name of Truvada

A

Prep 2004

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8
Q

1st approved drug by FDA for the treatment of Covid (oct 2020)
inh. RNA polymerase
adeults and childern ages 12 & older requiring hospitalization
weighting at least 88 pounds
dollars 520/vial- private
dollars 390/vial- govt

A

Remdesivir (Veklury)

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9
Q

1st PI(Protease inhibitors) approved for patient as young as 6 months

A

LOPINAVIR

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10
Q

LOPINAVIR approved for combination w/ _____
______ inh. Lopinavir metabolism by ______
causing a higher level of lopinavir in the system

A

RITONAVIR, CYP3A4

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11
Q

BRAND name of LOPINAVIR/RITONAVIR

A

Kaletra

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12
Q

Brand name of RITONAVIR

A

Norvir

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13
Q

Ritonavir, nelfinavir, saquinavir, indinavir and amprenavir are an antiviral agent for ______

Combination therapy w/ other agents is recommended to avoid the emergence of resistance, bcoz of specific genotypic alterations.

act once the provirus integrates into the host’s genes. it necessary to split viral precursor polypeptides into new virus.

HIV_____- maturation and propagation of new viruses

A

Protease inhibitors

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14
Q

A/E Syndrome of altered body fat distribution (buffalo hump and truncal obesity w/ facial and peripheral atrophy)
insulin resistance
hyperlipidemia

A

Protease inhibitors

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15
Q

S/E Diarrheam nausea, fatigue, H/A, inosmnia, dizziness

allows the DNA of the virus to merge w/ the DNA of the T cells
Raltegravir (isentress) 2007
Dolutegravir (tivicay) 2013
Elvitegravir
Bictegravir

A

Integrase inhibitors

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16
Q

(elvitegravir, emtricitabine, tenofovir alafenamide fumarate, cobicistat) 2015

A

Genvoya

17
Q

(elvitegravir, emtricitabine, tenofovir disoproxil, cobicistat) 2012

A

Stribild

18
Q

(dolutagravir, abacavir, lamivudine)

A

Triumeq

19
Q

(dolutEgravir, rilpivirine) 2014

A

Juluca

20
Q

(bictegracir,emtricitabine, tenofovir alafenamide fumarate) 2018

A

BIktarvy

21
Q

delavirdine, nevirapine,efavirenz is an antiviral agent for ____

A

Non-nucleoside reverse transcriptase INH.

22
Q

Bind directly to a site on the viral reverse transcriptase that is near to but distinct from the binding site of the NRTIs (Allosteric Site)
Neither compete w/ nucleoside triphosphates nor require phosphorylation to be active

A

PMOC LAB/LEC MIDTERM (2 decks)

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