Aspirin

Question 1

Presentation

Answer 1

300 mg chewable tablet

300 mg soluble or water dispensable tablets

Question 2

Pharmacology

Answer 2

An analgesic, antipyretic, anti-inflammatory and anti-platelet aggregation agent

Actions:
- to minimise platelet aggregation and thrombus formation in order to retard the progression of coronary artery thrombosis in ACS

Question 3

Metabolism

Answer 3

converted to salicylate in the gut mucosa and the liver; exerted daily via the kidneys

Question 4

Primary emergency indications

Answer 4

ACS

Question 5

Contraindications

Answer 5

1. H.S
2. actively bleeding peptic ulcer
3. bleeding disorders
4. suspected dissecting aortic aneurysm
5. chest pain associated with psychostimulant OD if SBP > 160 mmHg

Question 6

Precautions

Answer 6

1. asthma
2. peptic ulcer
3. patients on anticoagulants

Question 7

Route of administration

Answer 7

Oral

Question 8

Side effects

Answer 8

Heatburn, nausea, gastrointestinal bleeding,
Increased bleeding time
Hypersensitivity reactions

Question 9

Special notes

Answer 9

Aspirin is C/I for use in acute febrile illness in children and adolescents
The anti-platelet effects of aspirin persist for the natural life of the platelet.
onset: n/a
peak: n/a
duration: 8-10 days

Question 10

Dose

Answer 10

300 mg tablet