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CLTM Prep > ASM [Antiseizure Medications]/ Treatments > Flashcards

ASM [Antiseizure Medications]/ Treatments Flashcards

2020 AES Summary of ASM in the United States +

1
Q

adrenocorticotropic
hormone
(ACTH)

A

epileptic spasms

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2
Q

BRAND NAME of:
clonazepam
(CZP)

A

Klonapin

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3
Q

clonazepam (CZP) | Klonapin
FDA approved to treat…

A

LGS, myoclonic and absence seizures

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4
Q

BRAND NAME of:
felbamate
(FBM)

A

Felbatol

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5
Q

felbamate (FBM) | Felbatol
FDA approved to treat …

A

Adult refractory focal seizures
Adjunctive treatment in LGS

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6
Q

BRAND NAME of:
everolimus
(EVL)

A

Zortress, Afinitor

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7
Q

everolimus (EVL) | Zortress, Afinitor
FDA approved to treat …

A

Adjunctive Treatment Tuberous Sclerosis Complex assoc. focal Seizures

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8
Q

BRAND NAME of:
clobazam
(CLB)

A

Onfi

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9
Q

clobazam (CLB) | Onfi
FDA approved to treat …

A

Adjunctive Treatment for LGS

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10
Q

BRAND NAME of:
rufinamide
(RUF)

A

Banzel

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11
Q

rufinamide (RUF) | Banzel
FDA approved to treat …

A

Adjunctive Treatment for LGS

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12
Q

BRAND NAME of:
vigabatrin
(VGB)

A

Sabril

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13
Q

vigabatrin (VGB) | Sabril
FDA approved to treat …

A

Monotherapy: Epileptic Spasms
Adjunctive Therapy: Refractory FIAS (Focal Impaired Awareness Seizures)

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14
Q

BRAND NAME of:
fenfluramine
(FEN)

A

Fintepla

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15
Q

fenfluramine (FEN) | Fintepla
FDA approved to treat …

A

Dravet Syndrome

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16
Q

BRAND NAME of:
stiripentol
(STP)

A

Diacomit

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17
Q

stiripentol (STP) | Diacomit
FDA approved to treat …

A

Dravet Syndrome
as Adjunctive Treatment with clobazam

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18
Q

BRAND NAME of:
cannabidiol
(CBD)

A

Epidiolex

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19
Q

cannabidiol (CBD) | Epidiolex
FDA approved to treat …

A

Seizures associated with: LGS, Tuberous Sclerosis Complex, Dravet Syndrome

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20
Q

BRAND NAME of:
carbamazepine
(CBZ)

A

Tegretol

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21
Q

carbamazepine (CBZ) | Tegretol
FDA approved to treat …

A

Focal onset sz, GTC sz, mixed sz types

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22
Q

BRAND NAME of:
topirmate
(TPM)

A

Topamax

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23
Q

topirmate (TPM) | Topamax
FDA approved to treat …

A

Focal onset & GTC sz
Adjunctive treatment in LGS

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24
Q

BRAND NAME of:
valproic acid & divalproex sodium
(VPA)

A

Depakene, Depakote

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25
Q

valproic acid & divalproex sodium (VPA) | Depakene, Depakote
FDA approved to treat …

A

Monotherapy: focal onset & absence sz
Adjunctive treatment: multiple sz types, including absence

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26
Q

BRAND NAME of:
primidone
(PRM)

A

Mysoline

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27
Q

primidone (PRM) | Mysoline
FDA approved to treat …

A

Monotherapy: focal onset and Tonic Clonic sz’s

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28
Q

BRAND NAME of:
phenytoin
(PHT)

A

Dilantin

29
Q

BRAND NAME of:
fosphenytoin
(FOS)

A

Cerebyx

30
Q

Difference between phenytoin and fosphenytoin

A

-phenytoin is an oral med
-fosphenytoin is the IV formulation (used for status epilepticus and for short-term use when unable to give meds orally)

31
Q

phenytoin (PHT), fosphenytoin (FOS) | Dilantin, Cerebyx
FDA approved to treat …

A

focal onset & GTC seizures

32
Q

BRAND NAME of:
phenobarbital
(PB)

A

Luminal

33
Q

phenobarbital (PB) | Luminal
FDA approved to treat …

A

Focal & Generalized Onset seizures

34
Q

BRAND NAME of:
perampanel
(PER)

A

Fycompa

35
Q

perampanel (PER) | Fycompa
FDA approved to treat …

A

Focal Onset seizures
Adjunctive treatment for Primary GTC sz

36
Q

BRAND NAME of:
levetiracetam
(LEV)

A

Keppra

37
Q

levetiracetam (LEV) | Keppra
FDA approved to treat …

A

Focal onset seizures
Adjunctive Treatment: myoclonic sz in JME, primary Tonic Clonic seizures

38
Q

BRAND NAME of:
lamotrigine
(LTG)

A

Lamictal

39
Q

lamotrigine (LTG) | Lamictal
FDA approved to treat …

A

Withdrawal to monotherapy: Focal Onset
Adjunctive Treatment: Focal onset, LGS, primary Tonic Clonic Seizures

40
Q

BRAND NAME of:
ethosuximide
(ESM)

A

Zarontin

41
Q

ethosuximide (ESM) | Zarontin
FDA approved to treat …

A

Absence Seizures

42
Q

BRAND NAME of:
brivaracetam
(BRV)

A

Briviact

43
Q

brivaracetam (BRV) | Briviact
FDA approved to treat …

A

Focal onset sz

44
Q

BRAND NAME of:
gabapentin
(GBP)

A

Neurontin

45
Q

gabapentin (GBP) | Neurontin
FDA approved to treat …

A

Adjunctive treatment for focal seizures

46
Q

BRAND NAME of:
eslicarbazepine
(ESL)

A

Aptiom

47
Q

eslicarbazepine (ESL) | Aptiom
FDA approved to treat …

A

Focal onset seizures

48
Q

BRAND NAME of:
cenobate
(CNB)

A

Xcapri, Ontozry

49
Q

cenobate (CNB) | Xcapri, Ontozry
FDA approved to treat …

A

Focal onset seizures

50
Q

BRAND NAME of:
zonisamide
(ZNS)

A

Zonegran

51
Q

zonisamide (ZNS) | Zonegran
FDA approved to treat …

A

Adjunctive treatment for focal onset seizure

52
Q

BRAND NAME of:
tiagabine
(TGB)

A

Gabitril

53
Q

tiagabine (TGB) | Gabitril
FDA approved to treat …

A

Adjunctive treatment for focal onset seizures

54
Q

BRAND NAME of:
pregablin
(PGB)

A

Lyrica

55
Q

pregablin (PGB) | Lyrica
FDA approved to treat …

A

Adjunctive treatment for focal onset seizures

56
Q

BRAND NAME of:
oxycarbazepine
(OXC)

A

Trileptal

57
Q

oxycarbazepine (OXC) | Trileptal
FDA approved to treat …

A

Focal onset seizures

58
Q

BRAND NAME of:
lacosamide
(LCM)

A

Vimpat

59
Q

lacosamide (LCM) | Vimpat
FDA approved to treat …

A

Focal onset seizures

60
Q

Broad Spectrum ASMs (treat both focal and gen. onset sz)

A

brivaracetam (BRV) | Briviact
clobazam (CLB) | Onfi
felbamate (FBM) | Felbatol
lamotrigine (LTG) | Lamictal
levetiracetam (LEV) | Keppra
perampanel (PER) | Fycompa
rufinamide (RUF) | Banzel
topirmate (TPM) | Topamax
valproic acid & divalproex sodium (VPA) | Depakene, Depakote
zonisamide (ZNS) | Zonegran

61
Q

Narrow Spectrum ASMs (treat focal onset sz)

A

carbamazepine (CBZ) | Tegretol
cenobate (CNB) | Xcapri, Ontozry
eslicarbazepine (ESL) | Aptiom
gabapentin (GBP) | Neurontin
lacosamide (LCM) | Vimpat
oxycarbazepine (OXC) | Trileptal
phenobarbital (PB) | Luminal
phenytoin (PHT) | Dilantin
pregablin (PGB) | Lyrica
primidone (PRM) | Mysoline
stiripentol (STP) | Diacomit
tiagabine (TGB) | Gabitril
vigabatrin (VGB) | Sabril

62
Q

ASM for absence sz

A

ethosuximide (ESM) | Zarontin

63
Q

This AMS may worsen or precipitate myoclonic sz

A

lamotrigine (LTG) | Lamictal

64
Q

These AMS have a potential to worsen certain generalized sz types

A

eslicarbazepine (ESL) | Aptiom
gabapentin (GBP) | Neurontin
oxycarbazepine (OXC) | Trileptal
tiagabine (TGB) | Gabitril
vigabatrin (VGB) | Sabril

65
Q

Tell me about the ketogenic diet

A

The classic ketogenic diet (CKD) consists of a high-fat and low-protein and carbohydrate diet, with restricted calories and fluids. The diet mimics the fasting state, altering the metabolism to use fats as a primary fuel source; catabolism of fatty acids in the liver produces ketone bodies (KB), which induces urinary ketosis.

66
Q

Besides medication what other epilepsy treatment options are there?

A

Ketogenic diet, VNS (vagal nerve stimulator), DBS (deep brain stimulator), RNS (responsive neurostimulator)

67
Q

Bensodiazepines reduce

A

REM sleep

68
Q

Phenytoin at toxic levels makes EEG:

A

Slows alpha frequency to theta range
At higher toxicity levels delta activity appears.

69
Q

Side effect of phenytoin [PHT]

A

Gum hypertrophy and coarsening of facial features

CLTM Prep (6 decks)

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