Asfarviridae Flashcards
What is the sole member of Asfarviridae?
African Swine Fever Virus
Are Asfarviridae virons covered by an envelope?
Yes
Asfarviridae DNA Structure
Linear double-stranded DNA, single molecule
Where does the majority of replication occur by Asfarviridae viruses? Early replication?
Cytoplasm
Nucleous
What kind of prognosis would you expect for an animal infected with one of the more virulent strains of ASFV?
Poor
How long could ASFV particles survive in a pen after infected animals have been removed
30 days
In the bloodstream, what becomes attaches to monocytes and macrophages infected with ASFV.
Erythrocytes, this is called hemadsorption.
What arthropod is an important vector of ASFV?
Soft ticks (Ornithodorus)
What is the cycle where wild pigs infected with ASFV are bitten by ticks that then transmit the disease to domestic pigs?
Slyvatic
What are the 2 primary effects of ASFV?
- Hemorrhages
2. Apoptosis
4 sites of ASFV replication
- Pharyngeal mucosa
- Endothelial cells
- Megakaryocytes
- Macrophages
ASFV acute clinical signs
High fever Moderate anorexia Erythema Cyanotic skin blotching Respiratory signs Recumbency Vomiting Diarrhea, can become bloody abortion Death
ASFV chronic signs
Emaciation Swollen joints Ulcers Raised necrotic skin foci Pneumonia
On necropsy what would you see in the lungs of an animal that died from ASFV? Stomach? Spleen? Kidney? Lymph nodes
Lungs: Interlobular edema Stomach: Fundic congestion Spleen: Enlarged an friable Kidney: Petechia and Ecchymosis hepato gastric Lymph nodes: Enlarge and hemorrhagic
What is the first action after ASFV is suspected in a swine operation?
Report to authorities
