Asepsis/Infection Flashcards
Minute (tiny) organisms that cannot be seen by the naked eye
Microorganisms
Absence of pathogenic microorganism
Asepsis
Capable of producing a disease
Pathogenic
Not capable of producing a disease
Non pathogenic
Causes disease only in a susceptible host
Opportunistic pathogen
Invasion of body tissue by Microorganisms
Infection
Presence and growth of Microorganisms within a host but without tissue invasion or damage (ex. Some types of MRSA)
Colonization
Experiences localized symptoms (pain, tenderness, and redness) at wound site
Local infection
Affects whole body (can be fatal if untreated)
Systemic infection
Short and quickly forming infection
Acute infection
Slow forming and long presence of infection
Chronic infection
Neutrophils, Eosinophils, Basophils
Granulocytes
Monocytes, Lymphocytes
Agranulocytes
Segs/Polys
First phagocytes on the scene
Immature
Can be called band/stabs because they are unsegmented nuceli
Neutrophils
Weak but good at detoxifying allergens
Defend against parasites/help restrain hypersensitivity reactions
Eosinophils
Play a role in hypersensitivity reactions by secreting histamine, serotonin, and heparin
Decreases with allergic reactions
Basophils
Monocytes, lymphocytes
Agranulocytes
Monos Largest WBC Phagocytes Act more slowly than segs (neutrophils), but have a longer life, so they can consume more bacteria Seen with chronic infection
Monocytes
Lymphs
Originate in bone marrow and mature primarily on lymph nodes
Responsible for producing antibodies
Includes T & B cells
Lymphocytes
result from the delivery of health services in a health care faciilty
HAI -healthcare associated infection (nosocomial infection)
infection in which part of a persons normal flora becomes altered and overgrowth results
endogenous infection
infection that comes from microorganisms from outside of a persons body environment
exogenous infection
type of HAI from a diagnostice or therpeutic procedure
Iatrogenic infection
infectiosn that develop when broad spectrum antibiotics are used for a long period of time
-it kills the good bacteria
superinfection
general practices to reduce the number aand transfer of microorganisms to others and other things (clean technique)
medical asepsis
refers to practices which keep objects free from alll microorganisms (sterile technique)
surgical asepsis
- infectious agent 2. reservoir 3. portal exits 4. mode of transmission 5. portals of entry 6. susceptible host
chain of infection
permanent resident pathogens on the skin (normal flora)
resident pathogen
attach to skin during contact with another erson or object
transient pathogens
- # of microorganisms 2. pathogenicity (ability to produce disease 3. ability to enter/survive host 4. susceptibility of the host
potential for microorganisms to cause disease depends on these
the source for pathogenic growth
reservoir
the _____ ____ is the most common reservoir
human body
persons/ animals who have no symptoms but have pathogens
carriers
food, water, inanimate objects, insects
things that can be carriers
food, oxygen, moisture/water, right temperature, right pH, darkness
things that microorganisms need to survive
a mean of escape from the reservoir
portal of exit
route or means of contact (how it gets transmitted)
mode of transmission
infected person to noninfected person
direct transmission
personal contact of host with contaiminated inanimate object or animals
indirect transmission
fomites - instruments, utensils, needles, caths, drsg’s
vehicle borne
animals/ insects
vector borne
dust, droplets (tb)
airborne
skin and mucous membranes, respiratory tract, urinary tract, GI, reproductive tract, blood
portals of entry and exit
Intact skin and mucous membranes are the ____ _____ against disease
first barriers
degree of resistance the potential host has against microorganisms
susceptibility
heredity, age, nutritional status, stress, disease process, medical Tx,
things that susceptibility depends on
wounds, burns, travel, smoking, trauma, occupations, multiple sex partners
things that put you at risk
methicillin resistant staphyloccoccus aureus
mrsa
vancomycin resistant enterococci
VRE
gram positive organism that is usually sensitive to penicillin/ found mostly in dorms, prisons
MRSA
gram negative enterococci
VRE
spore forming anaerobic bacteria , usually acquired after long term antibiotic use
C diff
contolling/eliminating infectious agents, reduce reservoirs of infection, block the portal exits, control of transmission, control portals of entry, protect the susceptible host
steps in breaking the chain of infection
heat or cold, UV lights, gas, radiation
physical methods to eliminating infectious agents
sloutions used in various strengths to prevent growth and multiplication of microorganisms or kill them
chemical methods to eliminating infectious agents
prevents growth or reproduction of microorganisms
bacteriostatic
destroys microorganisms
bactericidal
substance used to destroy pathogenic microorganisms on inanimate objects
disinfectant
inhibits growth of bacteria / safely used on humans
antiseptics
destroys all microorganisms including spores and most viruses
sterilization
substance used on objects and people
germicide
limit contact with people who are infected or who have been exposed to infection
reduce reservoirs of infection
handwashing , treat all body substances as potentially infectious
block the portal of exits
handwashing, maintain good clean/sterile/isolation techniques, handle food, linen, dressings properly
control of transmission
handwashing, maintain aseptic technique, good wound care, good cath care
control portals of entry
handwashing, recognize high risk pts, hygiene, rest and sleep
protect the susceptible host
external nonspecific defense mechanisms, internal nonspecific defense mechanisms, specific defense mechanisms
defense mechanisms to fight infection
same responses with any type of injury
nonspecific body responses
anatomic structures are the _____ line of ______
first ; defense
skins acetic acid and salt concentrations, pH, secretions
biochemical responses
anatomic structures, biochemical factors, normal flora
external nonspecific defense mechanisms
vascular and cellular response, infalmmatory exudate production, tissue reparative phase
inflammatory response
delivers food, blood products, and nutrients to a local area of injury to protect against invasion and prepare the site for repair
purpose of inflammation
redness (rubor) heat (calor) swelling (tumor) and pain (dolor)
cardinal signs of inflammation
redness is caused by __________
vasodialtion
heat caused by vasodialtion from blood vessels close to the ________ of the skin
surface
swelling caused by _____ _________
fluid exudation (oozing)
pain caused by injured tissue releasing the chemical ______ which _____ _____ ________
bradykinin ; irritates nerve endings
body often tries to wall off the bacteria
loss of function
rest , ice, compress, elevate
RICE
tenderness, pain, swelling, drainage all occur in a ______ infection
local
fever, increased pulse rate, increased resp rate, fatigue, swollen lymph nodes, anorexia all occur in a ___________ infection
systemic
confusion, incontinence, aggitation, low grade fever
atypical (abnormal) signs of infection in an older adult
these are needed when nonspecific responses are ineffective
specific defense mechanisms
- originally from the bone marrow
- protects against bacterial, viral, and fungal infections, and provides resistance against tumor cells
- 70% of lymphocytes become t cells in the thymus
- travel to site of infection and release lymphokines which attracts macrophages to kill the antigens(bad stuff)
- occurs 2-6 days after antigen is introduced to the body
cellular mediated system
- other 30% of lymphocytes become b cells
- produce antibodies (immunoglobulins) that can destroy antigens
- takes about 5-7 days for them to become active
antibody mediated system
primary immune response ; formed during early response to antigen ; if in blood signifies and new active, or acute infection ; activates the complement cascade
IgM
IgM, IgG, IgE, IgA, IgD
types of immunoglobulins
series of events that destroys antigens cell membrane
complement cascade
any substance that causes your immune system to produce antibodies against it
antigen
- secondary response
- only immunoglobulin to cross the placenta barrier and gives infants passive immunity before birth
- protects against bacteria, viruses and toxins
- presence in the blood means there has been a past exposure to the organism and has probable immunity against the disease
IgG
-present in the blood in allergic or hypersensitivity reactions
IgE
- first line of defense against infections of the GI, respiratory, or urinary tracts
- prevents organisms from invading
- present in body secretions
IgA
regulates lymphocytes activation and suppression
IgD
healthy inflammatory response ; means we can recognize our own cells vs invading cells
immunocompetence
abnormal immune system
immunosuppressed
due to an antigen, antibodies are produced by the body in response to the infection
Active Immunity
natural contact with the antigen ; antibodies are formed in the presence of an active infection
Active Natural Immunity
immunization with an antigen which is often altered in the process
active artificial/acquired immunity
antibodies are given for a certain disease ; produced by another source- animal or human
passive immunity
antibodies are transferred naturally from an immune mother to her baby thru placenta, colostrums, or breast milk
passive natural immunity
immune serum from an immune human or animal are injected
passive artificial/acquired immunity
has no manifestations of the disease
asymptomatic
has symptoms and is in the course of infection
symptomatic
- determine the competence of the individuals immune system 2. #/type of tubes and invasive medical devices 3. duration of contact between host/microorganism 4. virulence of microorganism
assessing the risk factors the pt has
age, heredity, stressors, diseases, impaired skin integrity, altered body flora
determining the competence of the persons immune system
IVs, NGs, caths, drains
/types of drains and tubes
longer they are in the hospital the greater the exposure
duration of contact between host/microorganism
incubation , prodromal , illness, convalescence
stages of illness
interval between entrance of an antigen in the body and the appearance of symptoms
incubation stage
person is having nonspecific symptoms, most contagious stage, “just not feeling well”
prodromal stage
exhibiting obvious symptoms, depending on the site of infection, and the type of incetion
illness stage
the recovery period, sings and Sx dissapear
convalescence stage
5,000 - 10,000
normal WBC
indication for bacterial infections ; elevated WBC count
leukocytosis
indication for a viral infection ; decreased WBC count
leukopenia
assess for fatigue, fever, dehydration, tachypnea, tachycardia, cough, sore throat, pain etc
assess for fatigue, fever, dehydration, tachypnea, tachycardia, cough, sore throat, pain etc
chemo, steroids, trauma
can affect peoples immunity
increase in amount of immature WBCs specifically the bands
shift to the left
WBC count, cultures and sensitivity, xray of infected area, ESR, CRP
checking the pts diagnostic data
tells you what bacteria were found
culture
what antibiotic will be most effective
sensitivity
gives you clues as changes in tissue pathology from teh bacteria
Xray
shows that some type of inflammation if going on
erythrocyte sedimentation rate
vague test ; increases before ESR (6-10 hrs after infection)
C-reactive protein