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Parasitology/Virology > Arthropod and Rodent-borne Viruses > Flashcards

Arthropod and Rodent-borne Viruses Flashcards

1
Q

What is the family of Yellow Fever?

A

Flavivirus

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2
Q

How is Yellow Fever transmitted?

A

Mosquito

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3
Q

What are the two transmission cycles of Yellow Fever?

A

Urban - spread by mosquito that bit infected human

Sylvan (jungle) - mosquito probably bit infected monkey

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4
Q

What is the major target of Yellow Fever?

A

Liver

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5
Q

What is clinical presentation of Yellow Fever?

A 
Hepatitis, renal dysfunction
High fever
Black vomitus (hematemesis)
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6
Q

What are key points about the Flavivirus life cycle?

A

ss (+) RNA
Cytoplasmic replication
Viral assembly at ER and Golgi, not at plasma membrane

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7
Q

What is the family of Dengue fever?

A

Flavivirus

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8
Q

How many serotypes are there of Dengue?

A

4

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9
Q

How is Dengue transmitted?

A

Mosquito

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10
Q

What is the clinical presentation with 1st Dengue infection?

A

Acute infection

Fever, severe headache, myalgias and arthralgias, leukopenia, thrombocytopenia

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11
Q

What is the clinical presentation with 2nd Dengue infection?

A

Hemorrhagic fever or shock syndrome (DHF/DSS)

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12
Q

Why does a 2nd infection with Dengue cause different reaction?

A

Antibody-dependent enhancement of infection

In second infection, antibodies do not neutralize virus.
Antibodies enhance FcR-dependent attachment to, replication in, and cytokine release by monocytes/macrophages

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13
Q

What is the family of Hantavirus?

A

Bunyaviridae

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14
Q

How is Hantavirus transmitted?

A

Deer mouse feces, urine, or saliva

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15
Q

What is the clinical presentation of Hantavirus?

A

Hantavirus pulmonary syndrome (resembles acute respiratory distress syndrome)

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16
Q

What are features of Bunyaviridae family genome/structure?

A

Segmented (3 segments)
ss (-) RNA
Enveloped

17
Q

What are features of Arenaviridae family genome/structure?

A

Segmented (2 segments)
ss (-) RNA
Enveloped

18
Q

What family is Lassa Fever virus in?

A

Arenaviridae

19
Q

How is Lassa fever transmitted?

A

Rats

20
Q

What is the clinical presentation of Lassa fever?

A

Multiple organ system involvement

Fever, rash, hemorrhaging

21
Q

What population has higher death rates for Lassa fever?

A

Women in 3rd trimester of pregnancy

Fetus

22
Q

What potential therapy is there for Lassa fever?

A

Ribavirin

23
Q

What is the family of Ebola and Marburg viruses?

A

Filoviridae

24
Q

What are features of Filoviridae family genome/structure?

A

Enveloped
Filamentous
(-) ssRNA

25
Q

How is Ebola/Marburg transmitted?

A

Bats, monkey, contact with bat dropppings

Person to person

26
Q

What is the clinical presentation of Ebola/Marburg?

A

Fever, malaise, diarrhea, hemorrhage

Mortalities can vary, usually high

Parasitology/Virology (19 decks)

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