Arthritis Treatments Flashcards
1
Q
Non-Biological DMARDs
A
Methotrexate Leflunomide Hydroxychloroquine Sulfasalazine Gold
2
Q
Biologic DMARDs
A
Etanercept
Inflixumab
Abatacept
Rituximab
3
Q
Methotrexate
A
folate metabolism inhibitor (T & B cell)
4
Q
Hydroxychloroquine
A
inhibits macrophages, maybe TLR9 in dendritic cells
5
Q
Leflunomide
A
Pyrimidine synthesis inhibitor in T cells
6
Q
Sulfsalazine
A
Inhibits COX & scavenges free radicals (antigen presenting cells & T cells)
7
Q
Gold
A
reduces macrophage phagocytosis and affects antigen presenting cells & T cells
8
Q
Azathioprine
A
Blocks DNA synthesis, primary site of action T cell
9
Q
Cyclosporine
A
Calcineurin inhibitor to inhibit T cell activation
10
Q
Etanercept, Inflixumab
A
Block TNF action
11
Q
Anakinra
A
Interleukin 1 receptor antagonist
12
Q
Abatacept
A
Blocks T cell activation by antigen presenting cell (CD 80)
13
Q
Ritixumab
A
Blocks B cell activation (CD20)
