Arterial Insufficiency Ulcers Flashcards
-% of all lower extremity ulcerations are due to arterial insufficiency, or lack of adequate blood supply
5-10
What are the 3 layers of an artery from outermost to innermost?
- adventitia
- tunica media
- intimal layer
Describe the structure and function of the adventitia (tunica externa)
Composed of connective tissue along with collagen and elastin fibers.
It provides support to the vessel walls
Describe the structure and function of the tunica media
Made of thick, smooth muscle, collagen, and elastin.
It modulates vessel diameter
Describe the structure of the intimal layer
It is a single layer of endothelial cells in direct contact with circulating blood.
What are the smallest type of arteries?
arterioles
Pressure within the arterial system is normally between __-__ mmHg in larger arteries and as low as __-__ mmHg in arterioles
90-100
25-35
Describe the structure of capillaries
They are composed of a single layer of endothelial cells and are only 1 mm in length and are wide enough for a single RBC to squeeze through at a time
What are 6 causes of arterial insufficiency?
- Arteriosclerosis
- Trauma
- Acute embolism
- Diabetes mellitus
- Rheumatoid arthritis
- Thromboangiitis (Buerger’s disease)
What is arteriosclerosis?
thickening and hardening of the arterial walls
What is the most common form of arteriosclerosis and the leading cause of arterial insufficiency ulcers in the US?
Atherosclerosis
Describe the etiology of atherosclerosis
Circulating cholesterol is deposited on vessel walls, causing fatty streaks or plaques. The body attempts to repair the damaged endothelial cells, resulting in a buildup of blood products. Lipids, calcium, and scar tissue accumulating on the damaged intimal layer bulge into the lumen, causing progressive narrowing.
Atherosclerosis also leads to thickening of the basement membrane which results in what?
decreased exchange of oxygen and nutrients to affected tissues
What is one of the first signs of arterial insufficiency?
Intermittent Claudication
What is Intermittent Claudication?
Activity-specific discomfort due to local ischemia, which stops within 5 minutes of ceasing the provocative activity
Patients generally have at least __% vessel stenosis if they are experiencing intermittent claudication
50
The pain patients experience with intermittent claudication is typically _____ to the site of occlusion
distal
How does the body accommodate for increased tissue demands associated with intermittent claudication?
By decreasing the sympathetic output, thereby causing vasodilation
Once there is about __% vessel occlusion even maximal vasodilation does not provide sufficient circulation
70
What represents more significant arterial disease than intermittent claudication and is frequently characterized as a burning pain that is exacerbated at night or with elevation and is relieved by dependency?
Ischemic Rest Pain
Describe the progression of atherosclerotic pain
Intermittent Claudication –> Ischemic Rest Pain –> Ulcer
The prevalence of asymptomatic arterial insufficiency is _____ than that of symptomatic disease
greater
What can be used to describe dead tissue that is dry, dark, cold, and contracted when compared to similar areas or the contralateral side
gangrene
What ultimately results when local tissue oxygen requirements exceed perfusion?
ulceration and gangrene
Do arterial insufficiency ulcers tend to occur on the medial or lateral aspect of the limb?
lateral
What are 6 Risk Factors Contributing to AI Ulcers?
- Hyperlipidemia and Elevated LDL
- Smoking
- Diabetes
- Hypertension
- Trauma
- Advanced Age (70+)
What is the #1 modifiable risk factor for peripheral vascular disease?
smoking
What are the 4 ways in which smoking can contribute to arterial ulceration?
1) nicotine causes vasoconstriction, thus decreasing tissue perfusion
2) decreases the availability of oxygen by increasing the amount of nonfunctioning hemoglobin
3) increases the rate of clot formation and blood viscosity, thus decreasing tissue perfusion
4) nicotine enhances cholesterol deposition within vessel walls, thus hastening the atherosclerotic process and further impairing circulation
Smoking just one cigarette decreases wound and tissue oxygen saturation by __% for one hour in healthy individuals
30
People with diabetes have an increased prevalence of what type of arterial insufficiency?
Calcific, in which their vessel walls tend to accumulate calcium
True or False
Calcium deposits in the tunica media and basement membrane can be seen on x-ray
True
What effect does hyperglycemia have on wound healing?
decreases all 3 phases of wound healing and decreases the body’s ability to fight infection
Describe how HTN increases the risk of AI ulcers
It initiates and perpetuates endothelial cell injury
How do arteries respond to sustained hypertension?
By thickening the layer of smooth muscle within the tunica media and increasing the production of vasoconstrictive agents