Arnold Holmes Flashcards
Classification of head injury
mechanism morphology fractures concussion haematomas contusion severity
difference between confusion and delirium
Confusion = the inability to think as clearly or quickly as you normally do. You may feel disoriented and have difficulty paying attention, remembering, and making decisions.
Delirium is defined as an acute confusional state – it is a transient global disorder of cognition and also a medical emergency. (it is basically a specific form of confusion brought on by acute illnesses)
symptoms of confusion
Slurring words or having long pauses during speech
- Abnormal or incoherent speech
- Lacking awareness of location or time
- Forgetting what a task is while it’s being performed
- Sudden changes in emotion, such as sudden agitation
causes of confusion
Alcohol or drug intoxication
- Brain tumour
- Head trauma or injury
- Fever
- Fluid and electrolyte imbalance
- Diseases such as dementia
symptoms of delirium
Disorientation in time, space, person
- Impaired concentration and attention
- Altered cognitive state
- Impaired ability to communicate
- Insomnia
- Decreased cooperation in patient
- Exists in hypo- and hyperactive form
Hypoactive => withdrawn, sleepy and not interacting
Hyperactive => restless, agitated
causes of delirium
PINCH’S ME
Pain, infection, nutrition, constipation, hydration (+urine retention), sleep, medication and electrolyte imbalance.
RFs for epilepsy
Age: onset of epilepsy is most common in children and adults.
Family History
Head injuries
Stroke and vascular disease.
Brain infections: encephalitis
Babies born small for their age.
Babies who have seizures in the first month of their life.
Brain tumours
Cerebral palsy
Use of illegal drugs such as cocaine.
Having hyperexcitable neurones which get stimulated from triggers such as flashing lights, alcohol intake, alcohol withdrawal and sleep deprivation, mental exhaustion.
ddx for epilepsy
syncope cardiogenic/hypoT hypoglycaemia sleep TIA
Mx of epilepsy
General advice: Education to family members and individuals on how to recognise and manage seizures.
Advise to take showers, rather than baths.
Be cautious with swimming.
Be cautious with height
Be cautious with traffic
Be cautious when handling hot, heavy or electrical equipment.
Should inform the DVLA, they have seizures.
Avoid triggers.
As a general rule:
Sodium valproate, is used first line for patients with generalised seizures.
Carbamezapine, used first line for patients with partial seizures.
Can also have surgery.
MICA diazepam
MOA: benzodiazepam. Bind to GABA receptors in the brain and spinal cord, which increases the inhibitory effects of the GABA neurons.
Indications: muscle spasm, tetanus, anxiety, insomnia associated with anxiety, acute alcohol withdrawal, sedation, status epilepticus, febrile convulsions, convulsions due to poisons, acute drug induced dystonic reactions, dyspnoea associated with anxiety in palliative care, pain of muscle spasm in palliative
CIs: neonates via injection, chronic psychosis in adults, CNS depression, compromised airway, hyperkinesis, respiratory depression
Adverse effects: abnormal appetite, impaired concentration, movement disorders, muscle spasms, palpitations, sensory disorder, vomiting, constipation, diarrhoea, hypersalivation, slurred speech.
MICA phenytoin
M: Phenytoin is often described as a non-specific sodium channel blocker and targets almost all voltage-gated sodium channel subtypes. More specifically, phenytoin prevents seizures by inhibiting the positive feedback loop that results in neuronal propagation of high frequency action potentials.
I: tonic clonic seizures, focal seizures, prevention of seizures following surgery or head injury, status epilepticus
CI: 2d and 3rd degree heart block, SA block, sinus bradycardia
A: electrolyte imbalance, pneumonitis, vitamin D deficiency, arrhythmias, atrial conduction depression, cardiac arrest, hypoT
MICA sandoK
M: KCl, prevention of K depletion
I: established hypoK, usually prescribed with sodium chloride because infusion of Chloride ions promotes retention of potassium in the serum, whereas glucose may promote insulin release with resultant stimulation of sodium potassium ATPase, shifting potassium into cells.
C: Patients with renal impairment or oliguria as they are more susceptible to hyperkalaemia.
A: Overcorrection leading to hyperkalaemia, and a resultant risk of arrhythmias.
If infused rapidly or in too high concentration it can become an irritant to veins.
define DT
severe form of alcohol withdrawal that usually occurs 6-12hrs after their last drink
DDx for DT
sympathomimetic intoxication, encephalitis, meningitis, hypoglycaemia, Wernicke’s encephalopathy, benzodiazepine withdrawal, opioid withdrawal, thyrotoxicosis, schizophrenia
clinical features of DT
agitation, global confusion, disorientation, hallucinations, fever, high blood pressure, diaphoresis, and autonomic hyperactivity (tachycardia and hypertension