Approach to Collapse / Fall Flashcards
Differentials - neurological
Generalised seizure PD TIA / Stroke Vasovagal Situational syncope i.e. cough, micturition
Neuropathy - i.e. MS
Intracranial haemorrhages
Raised ICP
Generalised seizure
- hx
- exam
- ix
- mx
Hx
- tonic clonic - sudden LOC, stiff then jerk, incontinence, tongue biting, myalgia, confusion after
- absence (petit mal) - unresponsive, staring into space for a few seconds (typically in childhood)
- atonic - all muscles relax drop to floor
- tonic - all muscles rigid
- myoclonic - involuntary flexion
Exam
- may be post-octal
- focal neurology may indicate cause
Ix
- EEG if required
- find cause - CTH, U&E, cap glucose, drug levels
Mx
- treat cause
- anti-epileptics if >2 episodes
- IV lorazepam or PR diazepam to terminate acute seizure
- driving restriction
PD
- hx
- exam
- ix
- mx
Hx
- rigidity, tremor, bradykinesia, postural instability
Exam
- resting tremor
- shuffling festinant gait with lack of arm swing
- cogwheel rigidity
- bradykinesia
Ix - clinical diagnosis
- functional neuroimaging / dopamine transporter imaging (DaTscan) if diagnostic uncertainty
Mx
- Levodopa
- Dopamine agonists
- Monoamine oxidase inhibitors
- Physiotherapy + home modifications
TIA / Stroke
- hx
- exam
- ix
- mx
Hx
- Sudden onset neurological symptoms i.e. limb/face weakness, slurred speech, hemianopia
- RF - age, HTN, smoking, DM, vascular disease, AF
Exam
- neuro deficits - hemiplegia, HH, dysphasia
Ix
- CTH
- ECG - AF
- Coagulation screen
- Carotid dopplers
Mx
- Acute: anti platelet or thrombolysis if ischaemic stroke (+/- endovascular clot evacuation where available)
- Long-term: clopidogrel + statin + BP control
- Carotid endarterectomy - if stenosis >50% NASCET criteria /70% ECST criteria
Vasovagal
- hx
- exam
- ix
- mx
Hx
- occurs in response to stimuli i.e. pain, emotion, standing
- preceding pallor, sweating, nausea, closing visual fields then transient LOC
Exam - normal
Ix - clinical diagnosis
- tilt table test - if syncope diagnosis unclear
- consider ix to exclude other causes
- ECG normal
Mx - reassurance, avoid triggers
Situation syncope
- hx
- exam
- ix
- mx
Hx
- transient syncope in specific circumstance
Exam normal
Ix
- tilt table test if diagnosis unclear
- consider ix to exclude other causes
- ECG normal
Mx - reassurance
Differentials - cardiovascular
Postural hypotension
Aortic stenosis
Cardiac syncope
Structural - HOCM, arrhythmogenic RV dysplasia
Carotid sinus hypersensitivity - precipitated by head turning/shaving - dx by carotid sinus massage –> >3 second pauses
Vertebrobasilar insufficiency - vertigo precipitated by neck extension in elderly with OA
Subclavian steal syndrome - proximal subclavian artery stenosis causing retrograde flow in one vertebral arteries as they become involved in a collateral circuit to bypass the obstruction
Postural hypotension
- hx
- exam
- ix
- mx
Hx
- dizziness +/- LOC when sit to stand
- recently started anti-HTN
Exam
- postural BP of >20mmHg (systolic) or >10mmHg (diastolic) within 3 mins of standing
Ix
- U&E - dehydration
- CRP - infection
- FBC - anaemia
- Synacthen test - Addison’s
- Fasting glucose - diabetic autonomic dysfunction
Mx
- Treat cause - i.e. rehydrate, change anti-HTN
- Elastic stockings
- Sit to stand slowly
- Fludrocortisone if refractory
Aortic stenosis
- hx
- exam
- ix
- mx
Hx
- SOB and collapse on exertion
Exam
- ejection systolic murmur
- may be signs of LVF
- slow-rising pulse and narrow pulse pressure
- heaving apex beat
Ix - ECHO
Mx
- surgical valve replacement if severe or symptomatic
- TAVI if not fit
- ECHO f/u
Cardiac syncope (arrhythmia)
- hx
- exam
- ix
- mx
Hx
- fall and sudden LOC after transient arrhythmia
- may have palpitations or feel strange before collapse
- cardiac hx or FH of sudden death
- may occur during exercise or while supine
Exam - may be normal
Ix
- ECG - usually normal between attacks but may reveal cause i.e. WPW syndrome, Brugada syndrome, long-QT
- 24-hour tape
- Implantable loop recorder if episodes less frequent
- ECHO - look for structural heart disease
Mx
- depends on arrhythmia
- B-blockers or antiarrhythmics or ablation where appropriate
- ICD if risk of VT/VF
- Pacemaker if persistent symptomatic bradycardia, trifascicular block, Mobitz II, complete heart block or pauses >3 seconds
Other differentials (non neuro or CV)
Drug overdose / toxicity
Alcohol intoxication
Mechanical fall
Postural instability Polypharmacy Ectopic pregnancy Ruptured AAA Delirium Vertigo Hypoglycaemia Hypercapnic acidosis Sepsis Eyesight problems Arthritis Leg weakness Anxiety Factitious blackouts Heat syncope Multifactorial
Drug OD / toxicity
- hx
- exam
- ix
- mx
Hx
- hx of drug use or taking drug with narrow therapeutic index
Exam - depends on drug
Ix - drug levels and urine toxicology screen
Mx - depends on drug
Alcohol intoxication
- hx
- exam
- ix
- mx
Hx of alcohol use
Exam - odour of alcohol
Ix - ethanol level if required
Mx - observation
Mechanical fall
- hx
- exam
- ix
- mx
Hx - clear account of tripping, no LOC/syncope/sx
Exam - normal, check for injuries
Ix - consider ix to exclude other causes
Mx - reassurance and treat injuries