Approach to arthritis

Question 1

most common reasons for a septic monoarthritis is

Answer 1

hematogenous spead from other site - penumonia, pyelo, skin infection

Question 2

most common organism associated with septic arthritis

Answer 2

STaph aureus

Question 3

Someone with a disseminated gonoccocal infection and septic monoarthritis may present with

Answer 3

Skin lesions - ulcers

Question 4

Gout is correlated with

Answer 4

hyperurecemia in the blood

Question 5

Xanthine oxidase converts

Answer 5

Xanthine to uric acid

Question 6

Risk factors for gout

Answer 6

• illness
• surgery
• medications
  -alcohol consumption
  (renal failure, diuretics, ethanol)

Question 7

2 ways in which uric acid crystals induce inflammation

Answer 7

taken up by monocytes - release inflammatory cytokines
or by
neutrophils and lysozomal enzymes released

Question 8

precipitation of crystals in cartilage rather than synovium leads to

Answer 8

pseudogout

Question 9

typical joints in
gout
calcium pyrophosphate
hydroxyapatite

Answer 9

• First MTP (gout)
• Wrist, knee (pseudogout)
• shoulder, hip, first toe, young woman (hydroxyapatite)

Question 10

To diagnose monoarthritis

Answer 10

TAP!
culture
cells
crystals

Question 11

Always check what 2 organ systems when testing for arthritis

Answer 11

Liver

Kidney