APPP 09: Hematopoietic Systems Flashcards
What is the normal pH of blood?
7.35-7.45
How much blood do we have?
8% body weight
- 5-6 L in males
- 4-5 L in females
What are the 3 major functions of blood?
- transportation and distribution
- regulation and homeostasis
- protection and repair
What is the ‘transportation and distribution’ function of blood? (3)
- transports O2 and CO2 (respiration)
- transports nutrients and hormones
- pickup cellular and metabolic wastes for removal
What is the ‘regulation and homeostasis’ function of blood? (3)
- regulates pH
- regulates body temperature
- regulates water content of cells
What is the ‘protection and repair’ function of blood? (3)
- protects against blood loss (hemostasis)
- protects against infectious agents (inflammation)
- repairs wound and injury (wound healing)
What are the 2 components of blood?
- 45% formed elements (cellular elements)
- 55% plasma (fluid part)
What are the 3 formed elements?
- 5% platelets
- 95% red blood cells (erythrocytes)
- < 1% white blood cells (leukocytes)
What are the 5 types of white blood cells?
- neutrophils
- eosinophils
- basophils
- monocytes
- lymphocytes
What are the 6 components of plasma?
- electrolytes
- 90-92% water
- 7% proteins
- wastes
- nutrients/vitamins/hormones
- gases
What are the 4 proteins in plasma?
- 55% albumins
- 38% globulins
- fibrinogen (blood coagulation component)
- complement proteins and cytokines
What are the 3 gases in plasma?
- N2
- O2
- CO2
What are platelets?
cell fragments that are used for blood clotting
What are the 3 types of granulocytes?
- neutrophils
- eosinophils
- basophils
What is fibrinogen?
clotting factor
What do red blood cells (erythrocytes) do?
carry oxygen in the blood
What are the 3 types of globulins?
- alpha
- beta
- gamma
What do white blood cells (leukocytes) do?
responsible for all immune functions in fighting infections, tissue repair, and wound healing
What do alpha globulins do?
transport lipids/metals
What do beta globulins do?
transport hormones/vitamins
What do gamma globulins do?
immunoglobulins – antibodies
Ranking of red blood cells and white blood cells by number (highest to lowest).
- erythrocytes
- platelets
- reticulocytes
- neutrophils
- lymphocytes
- monocytes
- eosinophils
- basophils
Ranking of red blood cells and white blood cells by size (largest to smallest).
*(white blood cells > red blood cells > platelets)
- monocytes
- eosinophils, basophils
- neutrophils
- lymphocytes
- reticulocytes
- erythrocytes
- platelets
What are reticulocytes?
immature RBCs released by the bone marrow that mature into final RNC after 1-2 days in the peripheral circulation
What is the lifespan of erythrocytes?
100-120 days
What is the lifespan of platelets?
5-10 days
What is the lifespan of monocytes?
months
What is the lifespan of lymphocytes?
hours to years
- immune memory
What is the lifespan of neutrophils?
- 6 hours to a few days
- 1-5 days
What is the lifespan of eosinophils?
5-10 days
What is the lifespan of basophil?
a few hours to a few days
Describe the structure of erythrocytes (RBCs).
- anucleate, acidophilic cell
- also loses other organelles including most of its mitochondria
- biconcave disk (to achieve a maximum SA to cytoplasmic V ratio
- made up with hemoglobin for gas transport
What is hematocrit?
% erythrocytes in whole blood (total volume of erythrocytes relative to total volume of whole blood)
- 37-47% for women
- 42-52% for men
What is hemoglobin?
iron-carrying pigment
- normal range is age and sex-dependent
How many hemoglobins are there per RBC?
around 300 million – with a capacity to carry over 1 billion O2 molecules