applying PD/PK theory to exemplar drugs-psychoactive drugs 3; opioids Flashcards
1
Q
what is the most prevalent natural opiate?
A
morphine
2
Q
what opiate are there other than morphine?
A
codeine
heroin
3
Q
what is the only structural difference between morphine codeine and heroin?
A
the side chains
4
Q
what do these differences influence?
A
the pharmacokinetic profiles of these drugs
5
Q
fix these frugs from most lipid soluble to least
A
heroin>codeine>morphine
6
Q
what influences the pharmacodynamics?
A
structure
7
Q
how many carbons the side chain is supposed to have to activate the receptor?
A
2 or less
8
Q
what are the 2 most important binding site at opioid receptors for morphine?
A
nitrogen binding site–> ionic bond
hydroxyl binding site–> hydrogen bond
