appetite Flashcards
describe the blood glucose cycle
when we eat our blood glucose increases, when we have too much, insulin turn it into glycogen. When our blood sugar falls, glucagon turn glycogen back into blood glucose.
what is a set point
points in our weight at which we stop putting on/losing weight.
Muller er al 2010
when we exercise, we only lose weight up to a certain point, same if we put on weight, will only be up to a certain point
how does our brain know how much body weight we have
the hypathaliac nuclei receive inputs (leptin) as to how much adiposity you’re carrying, and this is able to alter the bodys weight through energy intake and metabolic activity in order to suit the set point.
leptin is detected by what
the arcuate nucleus
when you have too much leptin…
you have too muh body fat, the arcuate nucleus stimulates the release of anorexigenic hormones which suppress appetite. Released onto the lateral hypothalamus and inhibits the actions of it so the person has a suppressed appetite
when you have too little leptin
then orexigenic hormones are released by the arcuate nucleus onto the lateral hypothalamus which stimulates it causing the person to be hungry.
where does the orex and anor hormones bind to on the lateral hypothalamus
melanocortin receptor
what is ghrelin
hormone produced by the stomach in response to calorie intake
how does ghrelin wokr
if you have less calories going into your stomach then you will have more ghrelin which increases appetite
study about ghrelin
CUMMINGS 2004
found a correlation between ghrelin levels and hunger
homoeostasis
molecules in our blood tell the brain information about bodily functions, it is interpreted as a signal and then tells the brain how to maintain this. The hypothalamus is sensitve to the blood glucose levels and cells within the hypothalamus will adjust themselves according ti the blood glucose levels
basic feeding circuit
when we havent eaten, our blood sugar falls, the lateral hypothalamus is activated which tells us to go eat something, if you stimulate this, then it will increase appetite. Once we’ve eaten, our blood sugar increases, the ventromedial hypothalamus is activated and this tells us weve had enough food, if you stimulate this then you increase your level of satiety and then increase the amount you eat.
damage to feeding circuit
damage to either the LH or VH can cause the set point to be moved.
HETHERING AND RANSON 1942 found that by creating lesions on the VH in rats, it causes the rat to overeat and hence become obese, suggesting the VH is the satiety centre. HOWEVER GOLD 1973 found this was only the case when other part of the brain were activated suggesting more research is needed.
hedonic
what nerve is connected to the stomach
vagus nerve