appetite Flashcards

1
Q

describe the blood glucose cycle

A

when we eat our blood glucose increases, when we have too much, insulin turn it into glycogen. When our blood sugar falls, glucagon turn glycogen back into blood glucose.

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2
Q

what is a set point

A

points in our weight at which we stop putting on/losing weight.

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3
Q

Muller er al 2010

A

when we exercise, we only lose weight up to a certain point, same if we put on weight, will only be up to a certain point

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4
Q

how does our brain know how much body weight we have

A

the hypathaliac nuclei receive inputs (leptin) as to how much adiposity you’re carrying, and this is able to alter the bodys weight through energy intake and metabolic activity in order to suit the set point.

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5
Q

leptin is detected by what

A

the arcuate nucleus

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6
Q

when you have too much leptin…

A

you have too muh body fat, the arcuate nucleus stimulates the release of anorexigenic hormones which suppress appetite. Released onto the lateral hypothalamus and inhibits the actions of it so the person has a suppressed appetite

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7
Q

when you have too little leptin

A

then orexigenic hormones are released by the arcuate nucleus onto the lateral hypothalamus which stimulates it causing the person to be hungry.

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8
Q

where does the orex and anor hormones bind to on the lateral hypothalamus

A

melanocortin receptor

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9
Q

what is ghrelin

A

hormone produced by the stomach in response to calorie intake

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10
Q

how does ghrelin wokr

A

if you have less calories going into your stomach then you will have more ghrelin which increases appetite

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11
Q

study about ghrelin

A

CUMMINGS 2004

found a correlation between ghrelin levels and hunger

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12
Q

homoeostasis

A

molecules in our blood tell the brain information about bodily functions, it is interpreted as a signal and then tells the brain how to maintain this. The hypothalamus is sensitve to the blood glucose levels and cells within the hypothalamus will adjust themselves according ti the blood glucose levels

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13
Q

basic feeding circuit

A

when we havent eaten, our blood sugar falls, the lateral hypothalamus is activated which tells us to go eat something, if you stimulate this, then it will increase appetite. Once we’ve eaten, our blood sugar increases, the ventromedial hypothalamus is activated and this tells us weve had enough food, if you stimulate this then you increase your level of satiety and then increase the amount you eat.

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14
Q

damage to feeding circuit

A

damage to either the LH or VH can cause the set point to be moved.
HETHERING AND RANSON 1942 found that by creating lesions on the VH in rats, it causes the rat to overeat and hence become obese, suggesting the VH is the satiety centre. HOWEVER GOLD 1973 found this was only the case when other part of the brain were activated suggesting more research is needed.

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15
Q

hedonic

what nerve is connected to the stomach

A

vagus nerve

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16
Q

what is palatibility

A

the hedonic reward due to consuming foods that we find agreeable to the palate

17
Q

food reward circuit

A

the mesolimbic dopamine system.
dopamine is produced in the ventral tegmental area in the midbrain and passes along to the nucleus accumbens NESTLER 2001

18
Q

dopamine

A

allows us to learn about how to produce this rewarding feeling again as we make the connection. It ensures we learn about palatable foods and that we want to consume them again.

19
Q

blocking of dopamine

A

reduces consumption of palatable foods

20
Q

evolutionary trait

A

to seek out foods high in calories and to eat it at once to be able to be stored as fat.
This is due to our ancestors having scarce food and when finding food eating is as soon as.
This can provide an explanation for why we seek out palatable foods.