Apoptosis and necrosis Flashcards
1
Q
What is apoptosis?
A
Programmed cell death
2
Q
Describe apoptosis in normal cells
A
- Nucleus shrivels
- Whole cell shrivels
- Organelles get packaged into membrane bound vesicles and gets engulfed by macrophages
- Triggered in fully differentiated cell
3
Q
When does DNA apoptose?
A
If there’s any DNA damage
4
Q
When does apoptosis occur in development?
A
In hands, they start off all connected
5
Q
When does apoptosis occur in normal function?
A
Cells in the duodenum at the top wear out
6
Q
When does apoptosis occur in disease?
A
Excessive in HIV, T helper cells apoptose
7
Q
When doesn’t apoptosis occur in disease?
A
In cancer
8
Q
What is necrosis?
A
Traumatic cell death
9
Q
What are clinical examples of necrosis?
A
-Toxic spider venom
-Frostbite
-Cerebral infarction
-Avascular necrosis of bone: blood supply goes through neck of femur
-Pancreatitis: digestive enzymes obstructed will digest itself
10
Q
What is caseous necrosis?
A
-A particular pattern of necrosis
-Commonly seen in TB
