Apoprotein & lipoproteins

Question 1

apoA-1
Lipoprotein and additional remarks

Answer 1

HDL, Chylomicron
Activator of lecithin, cholesterol acyltransferase, ligand for HDL receptor

Question 2

apoA-2
Lipoprotein and additional remarks

Answer 2

HDL, Chylomicron
Structure is two identical monomers joined by a disulfide bridge

Question 3

apoA-4
Lipoprotein and additional remarks

Answer 3

Secreted with chylomicrons but transfers to HDL
Associated with formation of triacylglycerol rich lipoproteins; function unknown

Question 4

apoB-100
Lipoprotein and additional remarks

Answer 4

LDL, VLDL, IDL
Synthesized in liver, ligand for LDL receptor

Question 5

apoB-48
Lipoprotein and additional remarks

Answer 5

Chylomicron, chylomicron remnants
Synthesized in intestine

Question 6

apoC-1

Answer 6

VLDL, HDL, chylomicron
A possible activator of LCAT

Question 7

apoC-2
Lipoprotein and additional remarks

Answer 7

VLDL, HDL chylomicron
Activator of extrahepatic lipoprotein lipase

Question 8

apoC-3
Lipoprotein and additional remarks

Answer 8

VLDL, HDL, chylomicron
Several polymorphic forms depending on content of siahic acids

Question 9

apoD
Lipoprotein and additional remarks

Answer 9

Subfraction of HDL
Function unknown

Question 10

apoE
Lipoprotein and additional remarks

Answer 10

VLDL, HDL, chylomicron, chylomicron remnants
Ligand for chylomicron remnant receptor