Aplastic Anemia Flashcards
1
Q
What is Aplastic Anemia
A
Bone marrow failure caused by injury to the hematopoietic stem cell
2
Q
Most common cause?
A
Autoimmune suppression via a T-cell-mediated mechanism
3
Q
Causes
A
Autoimmune, toxins, radiation, congenital
4
Q
Clinical findings?
A
Weakness, fatigue, bleeding, pallor and purpura
5
Q
Hallmark lab finding?
A
Pancytopenia
6
Q
Essentials of diagnosis
A
Pancytopenia, hypo cellular bone marrow, and no abnormal hematopoietic stem cells observed
7
Q
What histology do we see?
A
Empty marrow
