apiprazole

Question 1

Brand name

Answer 1

Abilify

Question 2

Neurotransmitter action

Answer 2

dopamine partial agonist (binds to the receptor partially. In the presence of a lot of dopamine, it prevents some dopamine from having an effect. In the presence of little dopamine, it increases the overall effect).f

Question 3

Mania and psychotic symptoms can resolve in as little as

Answer 3

1 week

Question 4

May take up to _____ weeks to see symptoms

Answer 4

4-20

Question 5

Best augmenting combos

Answer 5

Valproic acid
Carbamazepine
Oxcarbazepine
Lamotrigine
Lithium
Benzos

Question 6

Side effects

Answer 6

Blocks alpha 1 adrenergic receptors: Dizziness, sedation, hypotension
Dopamine 2 partial agonist: Akathisia, nausea, vomiting

Question 7

Dosing for schizophrenia/mania

Answer 7

15-30 mg/day

Question 8

Dosing for augmenting SSRIs/SNRIs

Answer 8

2-10 mg/day

Question 9

Maintaina dosing

Answer 9

1. Initiate oral first to establish tolerability

2. After tolerability is established, administer initial injection along with a 14 day dosing of oral

Question 10

Drug interactions

Answer 10

1. fluoxetine increases plasma levels (CYP450 34A inhibitors)
2. Carbamazepine may decrease plasma levels (CYP450 34A inducers)

Question 11

Switching to apiprazole from asenapine, quetiapine, olanzapine

Answer 11

Taper off the original antipsychotic over 3-4 weeks

Start patient on a starting dose concurrently and then taper original antipsychotic

Question 12

Switching to apiprazole from clozapine

Answer 12

Taper off clozapine over 4 weeks or more while initiating apiprazole concurrently.