AP GU drugs

Question 1

Alpha blocker - main indication
(e.g tamsulosin)

Answer 1

Improves symptoms benign prostatic enlargement (BPH)
(lifestyle changes insufficient)

Add on treatment - resistant hypertension

Question 2

Alpha blocker - MOA

Answer 2

Binds + inhibits the alpha 1 adrenoreceptors in smooth muscle (blood vessels/ urinary tract - bladder neck + prostrate)

Leads to muscle relaxation/ vasodilation/ fall in BP/ reduced resistance to bladder overflow

Question 3

Alpha blocker - side effects

Answer 3

Postural hypotension/ dizziness/ syncope

Question 4

Alpha blocker - Contraindications

Answer 4

Existing postural hypotension

Question 5

Alpha blocker - Key interactions

Answer 5

+ anti-hypertensive drugs

Question 6

Anti- muscarinic - main indication (e.g Oxybutynin)

Answer 6

Bladder training ineffective
1st line treatment - overactive bladder
Reduce urinary frequency/ urgency/ incontinence