AP Gastro drugs

Question 1

PPI - indication

Answer 1

1) H.pylori eradication - triple therapy
2) GORD/ dyspepsia
3) Peptic ulcer disease
4) Long-term NSAID - gastro protection

Question 2

PPI - MOA

Answer 2

Irreversibly binds to the H+/K- ATPase in gastric parietal cells - reduces gastric acid secretion - targets the final stage of gastric acid secretion

Question 3

PPI - Side effects

Answer 3

Nausea/ hypomagnesaemia/ abdo pain

Increased risk of c.diff

Question 4

PPI - Contraindications

Answer 4

Caution - elderly - increased risk of osteoporosis + fractures

Can reduce/ disguise symptoms of gastric/ oesophageal cancer - important to check ‘ALARM’ symptoms

Question 5

PPI - Interactions

Answer 5

PPI - omeprazole + clopidogrel

Question 6

PPI - Monitoring

Answer 6

Long-term PPI use - check serum magnesium levels

Question 7

H2 receptor antagonists - indications

Answer 7

1) 2nd line GORD/ dyspepsia
2) 2nd line PUD
3) NSAID - gastro protection

Question 8

H2 receptor antagonists - MOA

Answer 8

Histamine H2 receptor antagonists irreversibly binds to the receptors on the proton pump inhibitor - which

Question 9

H2 receptor antagonists - side effects

Question 10

H2 receptor antagonists - Contraindications

Question 11

H2 receptor antagonists - Interactions