Aortic Dissection

Question 1

Aortic Dissection

Answer 1

Aortic dissection= a break in the inner intima layer of the aorta. refers to when a break or tear forms in the inner layer of the aorta, allowing blood to flow between the layers of the wall of the aorta. There are three layers to the aorta, theintima,mediaandadventitia. With aortic dissection, blood enters between theintimaandmedialayers of the aorta. Afalse lumenfull of blood is formed within the wall of the aorta.Intramuralrefers towithinthewallsof the blood vessel.

Question 2

Aortic Dissection: Classification

Answer 2

Aortic dissection most commonly affects the ascending aorta and aortic arch but can affect any part of the aorta. The right lateral area of the ascending aorta is the most common site of a tear of the intima layer, as this is under the most stress from blood exiting the heart. There are two classification systems.

The Stanford system:
- Type A– affects the ascending aorta, before the brachiocephalic artery
- Type B– affects the descending aorta, after the left subclavian artery

The DeBakey system:
- Type I– begins in the ascending aorta and involves at least the aortic arch, if not the whole aorta
- Type II– isolated to the ascending aorta
- Type IIIa– begins in the descending aorta and involves only the section above the diaphragm
- Type IIIb– begins in the descending aorta and involves the aorta below the diaphragm

Question 3

Aortic Dissection: Risk Factors

Answer 3

Aortic dissection shares the same risk factors as peripheral arterial disease, such as age, male sex, smoking, hypertension, poor diet, reduced physical activity and raised cholesterol.

Hypertensionis a big risk factor. Dissection can be triggered by events that temporarily cause a dramatic increase in blood pressure, such as heavy weightlifting or the use of cocaine.

Conditions or procedures that affect the aorta increase the risk of a dissection, such as:

• Bicuspid aortic valve
• Coarctation of the aorta
• Aortic valve replacement
• Coronary artery bypass graft (CABG)

Conditions that affect the connective tissues can also increase the risk of a dissection, notably:

• Ehlers-Danlos Syndrome
• Marfan’s Syndrome

TOM TIP: For your exams, a man aged around 60 with a background of hypertension, presenting with a sudden onset tearing chest pain, has aortic dissection. Marfan’s and Ehlers-Danlos syndrome are worth remembering as risk factors, as these may be options on an MCQ exam.

Question 4

Aortic Dissection: Symptoms

Answer 4

Aortic dissection can be difficult to spot. The diagnosis is often missed.
-asymptomatic
- acute onset, severe “ripping” or “tearing” chest pain+/- radition or migration. Anterior chest (ascending aorta) or back (descending aorta). Associated with abdominal pain.
- hypertension or hypotension as the dissection progresses
- Differences in blood pressure between the arms (more than a 20mmHg difference is significant)
- Radial pulse deficit (the radial pulse in one arm is decreased or absent and does not match the apex beat)
- weak or absent carotid, brachial, or femoral pulse
- Diastolic murmur, suggests aortic regurg
- Focal neurological deficit (e.g., limb weakness or paraesthesia)
- Collapse (syncope)

Question 5

Aortic Dissection: Management

Answer 5

Aortic dissection is asurgical emergencyand needs immediate involvement of experienced seniors, vascular surgeons, anaesthetists and intensive care teams. There is a very high mortality.

Analgesia(e.g., morphine) is required to manage the pain.

Blood pressureandheart rateneed to be well controlled to reduce the stress on the aortic walls. This usually involvesbeta-blockers eg. labetalol

Surgical interventionfrom the vascular team will depend on the type of aortic dissection.

Type Amay be treated with open surgery (midline sternotomy) to remove the section of the aorta with the defect in the wall and replace it with a synthetic graft. The aortic valve may need to be replaced during the procedure.
target systolic of 100-120 mmHg whilst awaiting intervention

TYPE B is just BP and pain control. conservative managment

Type Bmay be treated with thoracic endovascular aortic repair (TEVAR), with a catheter inserted via the femoral artery inserting a stent graft into the affected section of the descending aorta. Complicated cases may require open surgery.

Question 6

Aortic Dissection: Complications

Answer 6

There is a long list of complications. Some of the key ones to remember are:
- Myocardial infarction
- Stroke
- Paraplegia (motor or sensory impairment in the legs)
- Cardiac tamponade
- Aortic valve regurgitation
- Death

Question 7

Aortic Dissection: Investigations

Answer 7

AnECGandchest x-rayare often used to exclude other causes (such as myocardial infarction), although they may be normal and falsely reassuring. Myocardial infarction can occur in combination with aortic dissection, and treatment of the myocardial infarction (e.g., thrombolysis) can cause fatal progression of the aortic dissection.

CXR will show widened mediastinum

CT angiogramof chest, abdomen and pelvis is usually the initial investigation to confirm the diagnosis and can generally be performed very quickly.

MRI angiogramprovides greater detail and can help plan management but often takes longer to get.

Transoesophageal echocardiography (TOE) may be a useful investigation in clinically unstable patients with a suspected aortic dissection