Any + General Surgery Flashcards
1 What is an abscess?
A collection of pus, enclosed by a zone of active inflammation
Forms in response to:
- Pyogenic organisms resistant to phagocytosis or lysosomal destruction (S. aureus, S. pyogenes, E. coli, other Gram -ves
- Localised tissue necrosis
- Some organic foreign bodies e.g. wood splinters
Clinical features:
- Neutrophil leukocytosis
- Swining pyrexia
Management:
- Drainage
- Antibiotics (may halt expansion but rarely curative once abscess has fully formed
2 What is cancer staging?
The universal system for describing the severity of a cancer. The criteria are specific to each type of cancer but are related to properties of disease progression
- Tissue grade/histopathology (how closely it resembles normal tissue)
- Tumour size
- Numer of tumours (primaries and metastatic)
- Lymph node involvement
3 What modalities are used to stage cancer?
Each type of cancer has a preferred staging system, but commonly used systems include the TNM and Roman Numeral classifications
Roman Numberal
0 = in situ - abnormal cells are present but have not spread to nearby tissue. This is not cancer, but may become cancer
I = localised (invasion through basement membrane)
II = nodal spread (within primary organ)
III = regional spread (lymph nodes)
IV = distant spread (distant lymph node or metastasis via blood vessels)
TMN
Tis = carcinoma in situa
T1-4 = size and extent of primary
N0 = no regional lymph node involvement
N1-3 = extent of lymph node involvement
M0/1 = no mets/mets
4 What is the purpose of staging a patient’s cancer?
- Prognosis
- Management plan (curative vs palliative)
- Eligibility for various trials
5 What is neoplasia? Give examples of benign and malignant neoplasms
Neoplasia = abnormal growth of cells
Benign = slow, well-demarcated/encapsulated, similar histology to tissue of origin
E.g. adenoma, lipoma, fibroma, chondroma, haemangioma, papilloma, leiomyoma
Malignant = progressive/rapid, poorly defined, anaplastic tissue, pleiomorphic (nuclei of varying size and shape), stroma hyperplasia leading to characteristic tumour features (hard, obstruction, skin retraction)
E.g. carcinoma (e.g. SCC), sarcoma (e.g. GIST), leukaemia
6 What is a fistula?
Abnormal connection between two epithelialised surfaces
Causes
- Infection e.g. anal fistula following rectal abscess burst
- Inflammation e.g. Crohn’s disease
- Malignant growth or ulceration e.g. colon carcinoma
- Surgery e.g. biliary fistula after gallbladder surgery
Congenital e.g. rectovaginal fistula
7 What is a stoma?
An artificial anastomosis between a segment of the gastrointestinal or urinary tract and the skin of the anterior abdominal wall
Permanent: no remaining distal bowel segment
Temporary: emergency (relieve complete distal LBO to prevent perforation), defunctioning (diversion of faecal stream to protect the distal bowel)
Types
Loop = both proximal and distal segments drain to the surface, mainly for temporary defunctioning stoma
Split/spectacle = segmments brought to different skin sites
End = resite of anus to abdominal wall, usually permanent
Hartmann’s = emergency resection of rectosigmoid lesions where primary anastomisis isn’t advisable. May be rejoined months later
- What are the potential complications of a surgical procedure?
1. Anaesthesia
2. Operative
3. Post-operative
4. Medical comorbidities
—-
1. Anaesthesia
Local: injection site, infection, ischaemic necrosis due to vasoconstriction
Spinal/epidural: failure, nerve damage, vasodilation
General: electrolyte imbalance, cardio/resp/renal complications, hypothermia, reaction
2. Operative
Haemorrhage, tissue damage, inadequate operation, infection
3. Post-operative
Respiratory, VTE, fluid/electrolyte imbalance, AKI, pressure sores, paralytic ileus
4. Medical comorbidities
Decompensated HF, MI, arrhythmias, acute on chronic renal failure
9 What are the risk factors for a superficial wound infection
A superficial wound infection occurs within 30 days post-op and involves only skin and subcutaneous tissue with at least one of
- Purulent drainage
- Organisms isolated from aseptically obtained culture
- Infection (rubor, tumour, calor, dolor)
Patient factors
Older age, immunosuppression, obesity, DM, smoking, malnutrition, peripheral vascular disease, chronic skin disease
Treatment factors
Emergency procedure, hypothermia, oxygenation, prolonged operative time/hospitalisation, inadequate abx prophylaxis, not sterile technique
Environmental factors
Poor wound care, inadequate asepsis/sterilisation/ventilation
10 How do you treat a superficial wound infection?
Usually caused by commensal skin flora - primary staph and strep
Principles of management:
- Open and clean the wound
- Apply a protective, fluid-absorbing dressing
- Reserve abx for systemic illness or spreading cellulitis
Flu/di-cloxacillin = anti-staph (some strep cover) Cephazolin = 1st gen cephalosporin = gram +, some gram - cover Vancomycin = MRSA Tazocin = Piperacillin (ext spec) + tazobactam (B-lactamase inhibitor) = strep, staph, anaerobes, most gram -
11. What are the principles of antibiotic prophylaxis for surgical patients?
Goals
- Prevent surgical site infections
- Optimise the outcome of the patient’s surgical procedure
- Minimise adverse effects
- *Principles**
1. Right indication - not indicated for clean procedures if there is no proesthetic materal involved
2. Right antimicrobial agent - needs to cover skin flora at the site. Usually cefazolin
3. Right dosage - therapeutic and not toxic
4. Right timing - < 60 minutes before incision, ideally 15-30
5. Right route - IV
6. Right duration - 1 dose is usually sufficient
12. Why do surgical wound fail?
Operative
Opposing wound edges, poor aseptic technique, no prophylactic Abx
Wound under high tension → ischemia → dehiscence
Post-operative
Contamination, poor wound care
Patient factors
Increasing age
Stress
Comorbidities - diabetes, obesity, cancer, AIDS, smoking
Medications - steroids, anticoagulant and antiplatelet agents, chemotherapy, immunosuppressants
121 This patient has become aware of a skin abnormality for years that has developed hair growth during adolescence.
- What is the abnormality.
- What is its significance
- What treatment is needed?
Q1. Accessory nipple (occasionally becomes apparent during puberty, failure of regression of thickened endoderm during embryogenesis along mammary lines)
Q2. Supernumerary nipples are usually asymptomatic, but they can be of cosmetic concern to patients
Q3. Surgical excision - cosmetically unbearable, prevent pain/swelling during pregnancy
122 This is the abdominal photograph of an 80 year old woman who presents with a painful lump in the right groin. She has had it for 24 hours. Q1. What could it be? She has had generalized colicky abdominal pain from about 12 hours and some vomiting. Q2. What is the most likely diagnosis here? Q3. What is the most appropriate treatment strategy?
Q1. Hernia - inguinal or femoral
Q2. Strangulation
Q3. Immediate surgical repair, resection of any necrotic bowel
123 This lady had a swelling on the back of her lower neck. It has been present for years. It had slowly enlared over that time and is producing no other symptoms. Q1. What is the most likely diagnosis? Q2. What tests other than physical examination are likely to be helpful. Q3. What are the common complications of operative removal of this?
Q1. Lipoma (mature fat cells encased by thin fibrous tissue)
Q2. Investigations
Ultrasound - differentiate a lipoma from an epidermal cyst or ganglion
Biopsy - if painful, causes restriction of movement, rapidly enlarging, firm
Q3. Complications of Tx
Scarring, seroma, haematoma
Poor cosmesis
124 A 65 year old woman presents to the ED with vomiting, abdominal distention and colicky pain. She has never had an operation. She has a CT scan. Q1. What does this show? Q2. What does the surgical reistrar do the minute he sees this scan? Q3. What does he find? What is the treatment?
Q1. Small bowel obstruction, like secondary to hernia (if never had an operation)
Q2. Attempt to reduce the hernia
Q3.
ABCDE and appropriate resuscitation
2x IV large bore cannula - take FBC, group and hold, give fluids
Oxygen
Call for surgical consult
?GI decompression
Pain relief
Pre-operative Abx prophylaxis
Definitive - surgical repair
125 What is the massive transfusion protocol? In what circumstances should it be used?
Massive Transfusion Protocol (MTP) is the multi-disciplinary team management process for the critically bleeding patient anticipated to require massive transfusion. It outlines actions to be taken by the senior clinician attending to the patient, the transfusion laboratory staff, and the on-call haematologist/transfusion specialist.
Definitions:
- *• Critically bleeding** = major haemorrhage that is life-threatening and likely to require massive transfusion
- *• Massive transfusion** = half of one blood volume in 4 hours or more than one blood volume in 24 hours (adults)
Criteria for activation of MTP
• Actual/anticipated 4 units RBC in <4hrs + haemodynamically unstable ± anticipated ongoing bleeding
• Severe thoracic, abdominal, pelvic, or multiple long bone trauma
• Major obstetric, gastrointestinal, or surgical bleeding
126 A 75 year old lady was admitted with abdominal pain and vomiting, this Xray was taken. Q1. What are the possible causes of her small bowel obstruction? Q2. What are the priorities in managing her in the emergency department?
Q1. Causes of small bowel obstruction
- Extra-luminal: adhesion, hernia, volvulus
- Intra-mural: stricture, small bowel neoplasm (adenocarcinoma, GIST, etc.)
- Intra-luminal: intussussception, gallstones, impacted faeces, bezoar
Q2. Resus, NG tube decompression, pain management, surgical consult, NBM, prophylactic abx if for laparotomy
127 Q1. What is this structure and what operation is being attempted?
Q2. What symptoms would this patient have presented with?
Q3. What is the modern management of this condition?
(cholecystectomy)
Q1. Apparently is cholecystectomy (according to 2016 students)
Q2. Colicky RUQ pain, fever, Murphy’s sign
Q3. Laparoscopic cholecystectomy - preferably index admission procedure
129 Where is the appendix found?
Surface: right iliac fossa, close to McBurney’s point
Internal: blind ending arising from caecum, distal to ileo-caecal junction, at meeting point of the 3 teniae coli
Movement: suspended by mesoappendix (appendicular artery in free edge), rotates in arc around base, 30% pelvic, true retroperitoneal appendix lies behind caecum (can irritate R ureter and psoas when inflamed)
128 How do you categorise causes of abdominal pain?
- *Anatomical**
- RH: biliary pathology, hepatitis, lower lobe pneumonia
- EPI: peptic ulcer, gastritis, biliary, pancreatitis, AMI
- LH: splenic pathology, pancreatitis, lower bowel obstruction, lower lobe pneumonia
- RL: renal colic, appendicitis
- UMB: appendicitis (early), intestinal obstruction, mesenteric ischaemia, gastro, IBD
- LL: renal colic, lower bowel obstruction
- RI: appendicitis, inguinal hernia, IBD, female pathology
- HYPO/SUPRA: cystitis, urinary retention, dysmenorrhoea, endometriosis, PID
- LI: diverticulitis, female pathology, inguinal hernia
Mechanism
Inflammatory, ischaemic, mechanical, congenital, traumatic
Characteristics
Colic, peritonitis, diffuse, localised
130 When should you commence antibiotics in a patient who has symptoms and signs of appendicitis?
Initial treatment with antibiotic therapy alone may avoid the need for surgery in 60-80% of patients with uncomplicated appendicitis, but carries a 15-30% risk of readmission within one year and 40% at five years
The cornerstone of therapy is therefore surgical drainage and appendectomy
Empirical triple therapy (gent + ampicillin/amoxicillin + metronidazole)
If not perforated or no appendiceal abscess, discontinue following surgery
If complicated (perforation or appendiceal abscess), continue for 5 days, modifying Abx based on culture and sensitivity
131 What are the important differential diagnoses to consider when managing a 17 year old woman who has the symptoms and signs of appendicitis?
- *Gynaecological**
- Ectopic pregnancy
- Ovarian torsion/rupture
- PID
- Mittelschmerz
- *Gastrointestinal**
- Mesenteric adenitis
- Crohn’s disease
- PUD
- Cholecystitis
- Meckel diverticulitis
- *Urological**
- Pyelonephritis/UTI
- Ureteric stone
132 You (the candidate) are an Emergency Department resident. How would you proceed to manage a 22 year old female patient who presents to you with a 24 hour history of right iliac fossa pain?
Hx
- SOCRATES
- Bowel habits
- Recent flu/URTI
- Sexual activity
- Menstrual hx
- PMH: ongoing GIT, active/past malignancy, prev radiation, prev appendicetomy
Ex
- Vitals
- General inspection (still or writhing)
- Full abdo and pelvic exam
Inv
- B-hCG
- Urinalysis
- Bloods: FBC, UEC, LFTs, group and hold
- Abdominal and pelvic USS
Alvarado scoring:
M igration of pain
A norexia or ketones in urine
N ausea vomiting
T enderness RLQ
R ebound tenderness
E levated temp > 37.5
L eukocytosis > 10
S hift-left of leukocytes (neutrophilia > 75%)
133 What is the indication for imaging in suspected appendicitis?
Not essential to diagnosis, used to increase specificity and decrease negative appendectomy rate
Indications: suspected but dx unclear. The patient should not be so unwell that delaying surgery may lead to perforation
USS: specific but not sensitive, identifies ddx, lower diagnostic accuracy but quicker
CT: sensitive (rules out other ddx in older pts), higher diagnostic accuracy but slower