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PHAR0007 > Anxiolytics and hypnotics > Flashcards

Anxiolytics and hypnotics Flashcards

1
Q

What is anxiety?

A

It is a sympathetic reponse to fear, stress, or danger that results in sweaty palms, increased heart rate, dry mouth, etc. It can sometimes affect quality of life, and normal everyday situations - this is when an anxiety disorder is diagnosed.

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2
Q

Examples of anxiety disorders.

A

GAD, SAD, OCD, PTSD, phobias, panic disorder

Plus insomnia (trasient, intermediate and chronic)

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3
Q

What neurotransmitters are involved in anxiety?

A

GABA, 5-HT, NA [Glu]

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4
Q

What is the role of GABA in treatment of anxiety?

A

GABA is an inhibitory transmitter. It is the site of action of barbiturates and BDZs. Increased GABA-ergic transmission causes a decrease in anxiety.

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5
Q

What is the role of 5-HT in treatment of anxiety?

A

Increased 5-HT reduces anxiety.

5-HT(1a) agonists are anxiolytic.

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PHAR0007 (9 decks)

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