Adrenergics Flashcards
Drug names
alpha-1 effects
vasoconstriction, relaxation of GI smooth muscle, hepatic glycogenolysis, salivary secretion
alpha-1 agonists
alpha-1 antagonists
Phenylephrine, methoxamine
Prazosin, Doxazocin
alpha-2 effects
inhibition of transmitter release at nerve terminals, platelet aggregation, VSM contration, insulin release
alpha-2 agonists
alpha-2 antagonists
Clonidine
Yohimbine, Idazoxan
beta-1 effects
increased inotropic and chronotropic effects of the heart (increased CO)
beta-1 agonists
beta-1 antagonists
Dobutamine, Xamoterol
Atenolol, Metoprolol
beta-2 effects
bronchodilation, vasodilation, relaxation of visceral smooth muscle, muscle tremor, hepatic glycogenolysis
beta-2 agonists
beta-2 antagonists
Salbutamol, Salmetarol, Terbutaline, Formoterol, Clenbutarol
Butoxamine
beta-3 effects
relaxation of the bladder detrusor muscle, lipolysis, thermogenesis
beta-3 agonists
beta-3 antagonists
Mirabegron (agonist)
What does propranolol do? Where does it act?
B1/2 antagonist - an antihypertensive, for angina, dysrhythmias - a beta-blocker
What does guanethidine do?
An antihypertensive, acting on the NET.
Phentolamine
Non-selective alpha-1 antagonist for high blood pressure (mostly in emergency cases, and cocanie-induced cardiovascular problems). However, it affects the baroreceptors causing beta-1 receptors to fire and increase rate and force of contraction (therefore tachycardia). It also affects alpha 2 receptors and stops the negative feedback mechanism.
What do imipramine and tyramine do?
Imipramine is a TCA (reuptake inhibitor) and tyramine is a MAO inhibitor.
What type of receptors are alpha-1/alpha-2/beta?
Gq, Gi, Gs respectively
