Anxiety and stress Flashcards

1
Q

What is an anxiety disorder?

A

Abnormal and pathological fear and anxiety

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2
Q

What are the psychological features of Generalised Anxiety Disorder?

A

Difficult to control worry
Interrupted sleep
Poor concentration
Increased sensitivity to noise

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3
Q

What are the physiological features of Generalised Anxiety Disorder?

A
Sweating 
Dry mouth
Urinary frequency 
Hyperventilation 
Palpitations
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4
Q

What features must be present for a diagnosis of GAD?

A

Excessive anxiety/ worry occurring more days than not for at least 6 months about a number of events/ activities
3+ symptoms including: restlessness, fatigue, difficulty concentrating, irritability, muscle tension, sleep disturbance

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5
Q

What impact can GAD have on daily living?

A

Co-morbidities with physical conditions (e.g. chronic pain)
Affects work, social interactions, relationships
Increased suicidal ideation

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6
Q

What factors can predispose an individual to GAD?

A

Combination of biological, psychological and social factors

Neural activity associated with abnormal cognitions and increased attention to threat

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7
Q

What treatments can be used to manage anxiety?

A

Pharmacological treatments
Mindfulness
CBT (establishing links between physiological and psychological changes)
Thought diary

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8
Q

What is selective attention?

A

Seeing only the negative features in events

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9
Q

What is magnification?

A

Exaggerating the importance of undesirable events

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10
Q

What is overgeneralisation?

A

Drawing broad negative conclusions on the basis of a single insignificant event

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11
Q

What behaviours do anxiety treatments aim to target?

A

Selective attention
Magnification
Overgeneralisation

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12
Q

What are the 4 classes of the effects of stress?

A

Affective
Behavioural
Cognitive
Physiological

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13
Q

What behaviours or emotions are affective effects of stress?

A
Shock 
Distress
Anger
Low self-esteem 
Guilt 
Depression 
Anxiety/ fear
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14
Q

What are the behavioural effects of anxiety?

A
Smoking 
Alcohol 
Help seeking delay
Poor adherence
Social withdrawal 
Illicit drugs 
Sexual function
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15
Q

What are the cognitive effects of anxiety?

A
Poor attention 
Poor decision making 
Hypervigilance to threats
Memory loss
Learning difficulties
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16
Q

What are the physiological effects of anxiety?

A
Nervous system activation 
Hormone production 
Metabolic function 
Immune function 
Fatigue
Disease/ illness
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17
Q

How can the physiological effects of anxiety impact patients on the ward?

A
Poor wound healing 
Post-surgery complications 
Longer in-patient stays
More staff time 
More analgesia use
Poor adherence/ less satisfaction with treatment
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18
Q

How can the physiological effects of anxiety impact patients after discharge?

A

Longer recovery (e.g. return to work)
More service use
Less use of rehabilitation services
Increased risk of co-morbidity and early mortality

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19
Q

What 3 perspectives should be used to understand stress?

A

Stimulus (cause/ stressor)
Response (effect e.g. physiological)
Process (person-environment interaction)

20
Q

What is stress?

A

A non-specific physiological response to a threat to one’s physical or emotional wellbeing

21
Q

What are the 3 stages of a physiological response to stress?

A
  1. Alarm (fight or flight response - nervous, endocrine and immune systems activated for defence against threat)
  2. Resistance (conservation response initiated to return homeostasis) becomes counterproductive if alarm continues
  3. Exhaustion (depletion of physiological resources - collapse of adaptive responses, immune failures and disease outcomes)
22
Q

What is the transactional model of stress?

A

A causal chain of influence involving a stimulus event and and outcome influenced by intervening processes:

  1. Primary appraisal (determines significance of event)
  2. Secondary appraisal (evaluation of available response options)
  3. Response (coping - cognitive and behavioural activities initiated in order to manage demands of event)
23
Q

What does problem-focused coping involve?

A

Attempts to manage or change concrete aspects of the stressor

24
Q

What does emotion-focused coping involve?

A

Attempts to remove or reduce the emotional distress

25
What is the most effective coping strategy?
Flexible (mix of problem-focused and emotion-focused coping) Dependent on whether it is possible to change stressor
26
What is the difference between fear and anxiety?
Fear is an acute response to an actual stressor whilst anxiety is a response to a perceived or potential stressor (anticipation or unease)
27
What drug is commonly used to alleviate the physical symptoms of anxiety?
Propanolol (a Beta blocker)
28
Define fear
Acute response to an actual stressor - preparation for fight or flight behaviour
29
Define anxiety
Preparation for fight or flight behaviour in response to a perceived or potential stressor (e.g. anticipation or unease)
30
Define stress
A feeling of being overwhelmed by current situational, environmental or perceived pressures Effects can be emotional (e.g. depression), psychological (e.g. irritability) and physical (raised BP, fatigue)
31
How are anxiety and fear disorders classified?
Generalised Anxiety Disorder (often accompanied by Depression) Phobias (can be simple or complex) - including specific phobias, social anxiety, panic disorder and PTSD Obsessive Compulsive Disorders (inc. body dysmorphia)
32
Which areas of the CNS are involved in anxiety and fear?
Amygdala Higher cognitive centres (pre-frontal cortex) Insula (located within the lateral fissure) + other limbic system areas, association areas and sensory/ motor/ autonomic regions
33
Which brainstem region controls defence behaviours?
Periaqueductal Gray - contains high number of opioid receptors
34
What non-pharmacological management is available for anxiety and fear disorders?
Psychotherapy (behavioural) including conscious avoidance, relaxation, hypnotherapy and bibliotherapy
35
What pharmacological options are typically used to manage GAD?
SSRIs (Sertraline) SNRIs (Venlafaxine) Anti-epileptics (Pregabalin) Atypical antidepressants (Buspirone)
36
What is the MoA of Sertraline?
SSRI - selectively inhibits Serotonin reuptake on the presynaptic membrane increasing synaptic concentration of Serotonin in the CNS
37
What is the MoA of Venlafaxine?
SNRI - selectively inhibits Serotonin and Norepinephrine reuptake on the presynaptic membrane increasing synaptic concentration of 5HT and NE in the CNS
38
What is the MoA of Pregabalin?
AED - inhibition of voltage-gated calcium channels on the pre-synaptic membrane (thus modulating release of several excitatory NTs into the synapse)
39
What is the MoA of Buspirone?
Atypical - binds to 5HT 1A receptors on presynaptic membrane increasing NT levels in synaptic cleft Suppressed serotonergic action and enhanced firing of noradrenaline and dopamine
40
What pharmacological options are typically used to manage specific phobias?
SSRIs (Sertraline) | Beta-blockers (Propanolol)
41
What is the MoA of Propanolol?
Competetively binds to beta1-adrenergic receptors inhibiting sympathetic stimulation by preventing catecholamines (norepinephrine, epinephrine, dopamine etc.) from binding - results in reduced HR, cardiac output, BP etc.
42
What pharmacological options are typically used to manage panic disorders?
SSRIs (Sertraline)
43
What pharmacological options are typically used to manage PTSD?
SNRIs (Venlafaxine) SSRIs (Sertraline) Antipsychotics (Risperidone)
44
What is the MoA of Risperidone?
2nd Gen antipsychotic - inhibition of D2 (dopaminergic) and 5HT2A (serotonergic) receptors (5HT and D2 anatagonist)
45
What pharmacological options are typically used to manage OCD (inc. body dysmorphia)?
SSRIs (Sertraline) + TCA (Clomipramine) + Atypicals (Buspirone)
46
What pharmacological options are used acutely to manage crises?
Benzodiazepines (e.g. Lorazepam) | 'Z-drug' (Zolpidem)