Antivirals II Flashcards
List the five non-nucleoside reverse transcriptase inhibitors
Nevapirine Delavirdine Efavirenx Etrovirine Rilpivirine
Important things to know about Adenosine arabinoside
Severe effects
Only used with potentially lethal diseases
Deaminated in blood to less effective form
Important things to know about Foscarnet (phosphonoformic acid)
Competitive Inhibitor of DNA polymerase
Binds to Pyrophosphate sites
Inhibitor of RNA Pol and Reverse Transcriptase
Foscarnet is an especially effective inhibitor of…
Herpes DNA pol
How to administer Foscarnet?
IV only
Recommendations for when to give Foscarnet?
CMV retinitis
Synergistic with gancyclovir
Protease inhibitors for HIV target
The active site of aspartyl protease
First protease inhibitor licensed for HIV therapy
Saquinavir
Ritonavir is used as…
Supplementary booster treatment
Darunavir mechanism of action
Protease Inhibitor
Resists bacterial resistance development
When do you give Tipranavir?
Given with ritonavir as a salvage option for treatment-experienced patients with resistance to one or more protease inhibitors
Protease inhibitors used in Hepatitis C infection
Telapreir (+Interferon +Ribaviron)
Drug that acts by inhibiting the viral terminase complex
Letermovir in CMV (In Clinical Trials)
Significance of iSAVE therapeutics?
Peptides from C-terminal heptad repeat 2 region of the HIV-1 gp41 env glycoprotein. Made as secreted peptides by genetically modified T cells to protect nearby unmodified cells.
What do alpha and beta interferons do?
- Enhance MHC I and II expression
- Warn all local cells to shred any potential viruses around before its too late
