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Pharmacology 4 > Antivirals - HIV > Flashcards

Antivirals - HIV Flashcards

1
Q

NRTI Drugs?

A
  • Zidovudine
  • Tenofovir
  • Emtricitabine
  • Lamivudine
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2
Q

Truvada

A

1st line for HIV

comb of: Tenofovir + emtricitabine

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3
Q

Tenofovir

A

Adverse Effects
– renal insufficiency!!

Special consideration:
- Use w/ emtricitabine for pre/post exposure prophylaxis

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4
Q

Emtricitabine

A

adverse effects:
– Hyperpigmentation of the palms
– Skin discoloration

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5
Q

Lamivudine

A

Special considerations:

– caution using with Epivir HBV!

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6
Q

NNRTI Drugs?

A
  • Efavirenz
  • Rilpirivirine
  • Neviripine
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7
Q

Efavirenz

A

Adverse effects:
- CNS side effects (subside after 2 wks), Rash, elevated LFTs, teratogenic

Special Considerations:
- 600 mg @ bedtime on empty stomach, False-positive canabinoid test

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8
Q

Rilpirivirine

A

Indications:
-NOT in high viral loads

Special Considerations:
- Avoid PPI’s

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9
Q

Neviripine

A

Adverse effects:

- Hepatitis, fatal hepatic necrosis

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10
Q

PIs Drugs?

A

Lopinavir/Ritonovir
Ritonavir*
Atazanavir*
Darunavir*

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11
Q

Lopinavir/Ritonovir

A

Indications:

- Pregnancy (drug of choice)

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12
Q

Ritonavir*

A

Indications:

- Booster (not on its own)

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13
Q

Atazanavir*

A

Adverse effects:
- Indirect hyperbilirubinemia

Special Considerations:

  • No effect on lipids!
  • Avoid PPIs
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14
Q

Darunavir*

A

Adverse effects:
- Rash

Special Considerations:
- Caution in sulfa allergies

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15
Q

Integrase Inhibitor Drugs?

A

Raltegravir

Stribild

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16
Q

Raltegravir

A

Adverse effects:

-Increased creatine kinase

17
Q

Combination Products?

A

Combinations (one tablet PO daily)

  • Truvada®–> emtricitabine + tenofovir
  • Atripla® –> emtricitabine + tenofovir + efavirenz
  • Stribild® –> emtricitabine + tenofovir + elvitegravir + cobicistat
18
Q

Zidovudine

A

Adverse effects:

– Bone marrow suppression

Pharmacology 4 (3 decks)

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