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Antibiotx > antivirals/fungals > Flashcards

antivirals/fungals Flashcards

1
Q

Azoles

A

fluconazole
itraconazole
voriconazole

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2
Q

Azoles MOA

A

inhibits CYP450, dec prod ergosterol

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3
Q

Azoles SE

A

GI, inc LFTs

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4
Q

Amphotericin B MOA

A

binds ergosterol and forms pores in cell memb

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5
Q

amphotericin B SE

A 
infusion related (fever/chills/V/HA)
cumulative tox (renal)
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6
Q

echinocandins

A

caspofungin
micafungin
anidulafungin

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7
Q

echinocandins MOA

A

inhibit synth B (1-3) glucan, disrupts cell wall

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8
Q

echinocandins Se

A

GI, flush

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9
Q

Neurominidase inhibitors

A

oseltamivir

zanamivir

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10
Q

nerominidase inhib MOA

A

analogs sialic acid, interferes w release of progeny influenza virus from infected cells

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11
Q

neurominidase inhib Se

A

oselt-NV abd pain, HA, fever diarrhea, CNS

zana-cough, bronchospasm, dec PFT, nasal/throat

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12
Q

M2 blockers

A

amantadine

rimantadine

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13
Q

M2 blockers MOA

A

block M2 proton channels of virus inhibiting uncoating of viral RNA in host cell
against influenza A ONLY

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14
Q

m2 blockers SE

A

GI (nausea/anorexia), CNS, severe behavioral changes, delirium, agitation, sz

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15
Q

antivirals for HSV/VZV

A

acyclovir

valacyclovir

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16
Q

antivirals for HSV/VZV MOA

A

inhib DNA synth (binds DNA template)

17
Q

antivirals for HSV/VZV Se

A

N/D HA

18
Q

antivirals for CMV

A

ganciclovir

valganciclovir

19
Q

antivirals for CMV MOA

A

acyclic guanosine analog, termination of DNAelongation

20
Q

antivirals for CMV SE

A

myelosuppression, ND, fever, periph neurop

21
Q

Azoles use

A

candida, blastomyc/coccidoido/histo, aspergillus

22
Q

Amphotericin B use

A

broadest spectrum, severe life threatening infx

23
Q

echinocandins use

A

candida, aspergillus

Antibiotx (3 decks)

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